RE: Personalised-cancer-treatment5 Sep 2023 06:29
Good morning Andy
Personalised medicine is what PYC do ànd is what their dosing tool does (see Januarry 2023 RNS)
They have an A.i/ machine learning dosing tool and the FDA are warning drug conapnies to use these tools if they want to have FDA clearnec e,it is FDA guidelines called Project Optimus
pyc published their findings at the April 2023 AACR and also have their work published in the world famous Frontiers magazine
See below the RNS about about it from April_May 2023
Project Optimus has relevance to Physiomics both in its core consulting business and its personalised oncology initiatives. In core consulting, Project Optimus encourages and some would say even mandates biotech and pharma companies to fully utilise all available non-clinical and clinical data to make informed decisions about clinical trial design and biologically effective dose. The Company believes that there is an increasing expectation that companies meeting with the FDA should have utilised mathematical modelling in support of clinical trial design and dosing decision making. The Company has first hand experience of this through the translational modelling work it has completed for multiple small and medium sized clients in recent years.
Looking beyond drug development, the Company sees a clear implication of Project Optimus on dosing of approved drugs in cancer. The vast majority of cancer drugs are still approved on a "one size fits all" basis with, at most, adjustments in dosing being made to account for body weight or surface area of individual patients. The Company believes that the future direction of cancer drug dosing will take into account its effect in each individual and we believe that our personalised dosing tool is a clear step towards achieving that goa