RE: Onclive23 Apr 2024 12:27
The 90% refers to the probability of repeating existing data. Page 10 of the 2023 AGM presentation states: “Greater than 90% probability of replicating this data in the full cohort of 43 patients .”
https://www.scancell.co.uk/Data/Sites/1/media/docspres/agm-presentation-november-2023.pdf
In the 2023 AGM presentation, Lindy says:-
“Again if you like your stats and I’m not going to argue stats with you because I’m not an expert, they tell me if I get 9 out of 11 responses there’s a 90% probability that we will meet that milestone of 27 out of 34 which is really exciting”.
https://www.youtube.com/watch?v=say9mRBFzCo
This is a fuller version of what Lindy says from about 6 minutes in, talking about metastatic melanoma:-
“Metastatic melanoma until very recently, probably five years ago was a death sentence, there was no therapies doesn’t respond to chemo, nothing works in metastatic melanoma. The double checkpoints have now improved that to 50% our intention was to improve that 50% t0 70% because the clinicians told us that would be a meaningful impact for these patients, but a really tough ask, there have been many combination studies in this area that failed to achieve that but we’ve got better than 70% as you can see we smashed it at 82%. So we were supposed to see 9 patients out of 15, we actually saw those 9 responding patients and I’ll show you that data, out of 11 patients. That’s an 82% response, even more exciting there was no toxicity associated with the melanoma vaccine. The checkpoints themselves particularly one of them can be quite toxic but the addition of the vaccine had no additional there at all which again is really good in combinations. So we now move to the second stage, so the first one we had to see 9 in 15, the second stage we need top see 27 responses in 43 patients, or if we see this 82% response rate it will be 27 in 34 patients. Today as we talked to you as its changed again there it’s 21 patients that have been immunized so we’re pretty much going down that route, we only have to get 34 so hopefully proably early next yearwe will finish that but you need to bear in mind they do need to be on the study for at least 3 months to that first scan when we get that first response to see whether they’ve got an objective response. So hopefully sometime in the next half next year we should get that data and see how good it is. Again if you like your stats and I’m not going to argue stats with you because I’m not an expert, they tell me if I get 9 out of 11 responses there’s a 90% probability that we will meet that milestone of 27 out of 34 which is really exciting”.
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