Fud248 your being totally naive if you think news isnt known. RNS would have been logged a few days ago. Hence the speculative buying however the news wasnt the big one hence sellers.
Its been a good start to the year, however big news is needed to propel the company above 200M MKT CAP
I also think ORPH is a bit of a leaky ship and buying for this announcement started a few days ago, SP will probably end red with the sell on the news brigade.