The science around5 Mar 2019 16:33
Immune suppression development will not stop at PD-1 ...
Stevenage, United Kingdom – September 28th 2018: Tusk Therapeutics Ltd (“Tusk”) was today acquired by Roche. Tusk has developed an antibody with a novel mode of action aimed at depleting regulatory T-cells (Tregs). Tregs suppress immune responses, including those against cancer cells. Preclinical data has shown that depleting Tregs from the tumor microenvironment can enhance and/or restore anti-tumor immunity. Tusk’s antibody has been designed to deplete these harmful Tregs, while not interfering with other immune cells acting against the tumor. Tusk’s program is expected to start clinical trials in cancer patients towards the end of 2019.
Roche will pay up to $759m for its acquisition of Tusk Therapeutics, a UK-based company which develops immuno-oncology treatments. The payments will be made with €70m ($81m) upfront with up to €585m ($678m) being payable in milestones.
so i would not worry about SP growth when it happens
that should enter trial soon ... if it works .. It could work with SCIB1 and keytruda ...
It could also potentially help flip the Immunosuppressive Cd4+cd25 t cell regulatory cells with Moditope .....
is Genentech out of the picture ?
No