Member Info for Grailor

Oasis - I would be extremely surprised if there was a 'bonus' linked to the clinical trial outcome as that would be totally unethical!!
I also think that confirmation of MHRA approval for the Covid CHIM study would be extremely impactful news!!

Rosco - I do think we will hear about the challenge study when approved. For one it will be registered on Clintrials.gov for all to see and secondly they will be advertising for healthy vols to participate - so impossible to keep out of the 'news'.

Agreed ;)

I'm with Lloyds and still have not got mine!!

Things are becoming so predictable here I am beginning to think I should started trading it!!

It will be a landmark approval and I can't believe CF won't shout it from the tree tops!

Just wondering when we are likely to hear about MHRA approval for the Covid challenge study, thoughts?

Also, we and the market already knew the Prep news released in the RNS today - remember the in depth discussions we had about it last week?? So the RNS 'old news' was never going to have a major impact IMHO.

DJ - agree and so does the market - steady decline in SP over the last 3 months now - proof and pudding!!

Agreed. Perhaps we should ask Ryan how they intend to fund a Ph2b study??

"We are excited about these new data allowing us to dose PrEP-001 daily for up to 12 weeks which is the expected length of a typical cold & flu season. We intend to move forward with a field trial to assess the efficacy against a number of common respiratory viruses and provide real world validation of PrEP-001 as a novel pan-viral prophylaxis," said Ryan Muldoon, CEO of PrEP Biopharm Limited.

JH - just reiterating whats stated in the announcement. A Phase 2b study is going to cost them in the order of $7-10M. Perhaps some of the OO capital will be invested in that study??

Ryan Muldoon - states that they intend to move forward with the Ph2b study - so who knows!

Thanks Eskers, more detail here.
https://www.prnewswire.com/news-releases/prep-biopharm-limited-announces-successful-completion-of-prep-001-toxicology-study-enabling-phase-2b-field-study-of-prep-001-against-all-respiratory-viruses-301194520.html

Moni - I hope they are all nicely tucked up in your ISAs ;)!

In all honesty the article doesn't say that the Codagenix study is a challenge study, it says that the companies have not shared that info - if they had looked on Clintrials.gov they would have got there answer . It does say that OO are planning to start both the IN Codagenix study and a challenge study in January. It would be great to get confirmation that the challenge studies have got MHRA approval - that should shift the SP!!!
'While the companies have not shared if this trial would be part of Open Orphan’s human challenge trials, the company is preparing to begin testing the method in January as well. The controversial trial method is said, by advocates, to be a quicker and safe method of testing a vaccine.'

Hi Czarboy - would be interested in your view on Flu-V and why it has been sat on the shelf for a couple of years now - pending a Phase 3 study start - any opinion??

Desert - take a look at Clintrials.gov, it describes the Codagenix study in detail - it isn't a challenge study. We have not yet received MHRA approval for the challenge studies.

Well that article is clearly wrong wrt a challenge study . The Codagenix study is a standard Phase 1 study, no mention of a challenge component.

Big MJ - me too. I guess we fell off the radar given that things have been a bit 'quiet' over the last number of months. Lets hope we LTH's get our due rewards for the years of patience!!

Where?? Don't think that's been approved yet???