RE: Woo Woo28 Apr 2020 09:00
Key cytokines that are found elevated in Covid-19 patients that have been admitted to intensive care include IL-2, IL-7, IL-10 and G-CSF*, all of which signal via JAK-family kinases. As the Company noted in its half yearly report, a paper in the European Respiratory Journal published in 2017** suggested that TYK2 inhibition might be effective in the treatment of influenza driven secondary bacterial pneumonia, which is potentially highly relevant against the backdrop of the Covid-19 pandemic. The Company also notes that it is preparing grant applications to fund studies to assess the potential use of its TYK2/JAK1 inhibitors to address this threat to global public health.