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https://www.labonline.com.au/content/life-scientist/news/disappointing-results-for-who-s-covid-19-therapeutics-trial-118303326

https://www.globenewswire.com/news-release/2020/10/20/2110915/0/en/Parexel-Biotech-Collaborates-with-Synairgen-on-Pivotal-Phase-III-Trial-for-Study-of-Inhaled-COVID-19-Treatment.html

https://www.medgadget.com/2020/10/aerosol-delivery-devices-market-to-exceed-usd-46-72-billion-by-2027.html

Coronavirus (COVID-19) was discovered in late December in Hubei province of Wuhan city in China. There are no drugs that are currently licensed for COVID-19 treatment or prevention. Increase in number of R&D activities and rise in use of aerosol delivery devices in clinical studies to develop medicines for treatment of COVID-19 is anticpated show positive impact on the market. For instance, Synairgen a UK-based respiratory drug discovery & Development Company launched home-based clinical trial of its inhaled IFN-ß1a solution (SNG001) in patients with COVID-19.The dry powder inhalers (DPI) segment will show significant aerosol delivery devices market growth during the forecast period, owing to rise in demand for DPI, surge in patient awareness toward effective & advanced respiratory devices, advancements in DPI drug delivery, and launch of cost effective products.

https://news.sky.com/story/coronavirus-this-is-what-a-second-wave-looks-like-12102895

We need SNG001...........Inhaled now!!

Now then!

https://news.sky.com/story/donald-trump-could-become-ill-with-second-wave-of-coronavirus-within-days-lung-doctor-warns-12091651

Donald Trump could become seriously ill with a "second wave" of COVID-19 within days, a leading lung specialist has warned.

Professor Stephen Holgate, a respiratory specialist at University Hospital Southampton NHS Foundation Trust, told Sky News the decision to allow the US president to leave the Walter Reed military hospital was "not textbook".

"The disease can get worse very quickly," he said.

"He is still in the first wave. The second is yet to come, when the immune system goes into overdrive. It will probably hit him in two to three days' time."

https://clinicaltrials.gov/ct2/show/study/NCT04385095?cond=SNG001&draw=2&rank=1

Loosing control..........Universities, Schools, all of the U.K. reporting higher numbers. Somethings got to give. Then theirs the most powerful man in the World ripping his mask off after treatment.
Mad

A spokesman for Epsom and St Helier NHS Trust said: A small number of patients have tested positive for COVID-19 during admission to the Renal Department and Intensive Care Unit at St Helier Hospital.

'The safety and wellbeing of our patients and staff is our priority and those who tested positive have been isolated from other patients, with arrangements in place to maintain safe and high-quality care.'

They added: 'We continue to follow all relevant infection prevention and control guidelines.

'Visiting has been restricted for some areas, as soon as clinicians are confident that the measures can be lifted in a way that is safe for patients and staff, they will be.'

It comes as surgeons call for hospital beds to be 'ring-fenced' for planned operations, to avoid a 'tsunami of cancellations' due to rising Covid-19 cases.

A survey for the Royal College of Surgeons of England found most surgeons thought the NHS could not meet its targets to get surgery back to pre-pandemic levels.

You would think the U.K. Government would get the message...........synairgen interferon nebuliser

For example, if your family member was diagnosed with a viral infection, you could potentially treat the rest of the family members with prophylactic IFN, and healthcare workers or people who are exposed to high-dose virus on a daily basis

Topol: A paper just came out in Nature Reviews Immunology that reviewed four small ongoing trials and that multicenter study from China. All of them look quite promising. If you were to predict the future, do you envision that we all could have an inhaler with an IFN that we would take at first diagnosis or exposure? Do you think that's a possibility?
Iwasaki: As long as we can give the right dose without toxicity, that may be the future, especially in a preventive setting. For example, if your family member was diagnosed with a viral infection, you could potentially treat the rest of the family members with prophylactic IFN, and healthcare workers or people who are exposed to high-dose virus on a daily basis. That's what happened in China; they gave an inhaled IFN to healthcare workers and none of them were infected. So this may be a good thing to do in the future

Dr Foxman said this response - the interferon response is known to work against Covid-19.

She added: "If you do the experiment in a lab, you can apply this chemical - interferon - to cells, then you can block the virus that causes Covid-19 as well.

"So it's possible that we'll see the same thing, but we're just beginning to do the experiments.

"Sometimes you see unexpected things happening so you have to just do the experiment and see what the result is and that that's just a work in progress at the moment."

She added that interferon-based immunity lasted up to two weeks, but highlighted that it did not prevent infection forever.

Dr Foxman explained it may provide a "temporary buffer against getting another virus" while the body is all "revved up" to fight it.

https://www.express.co.uk/news/politics/1343604/Brexit-latest-cancer-wonder-drugs-matt-han****-project-Orbis

Could the Tweet be correct.............Lots of falsehoods coming out?

President Trump's access to medical care will be far superior and more timely than that of the average American. He will receive inhaled Type 1 interferon, Regeneron's monoclonal antibody ****tail, REGN-CoV2, and remdesivir immediately after his diagnosis. His prognosis is good

https://www.nationalgeographic.co.uk/science-and-technology/2020/10/what-president-trumps-emergency-covid-19-therapies-say-about-his

https://mobile.twitter.com/realDonaldTrump/status/1312525833505058816?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Etweet

https://www.dailymail.co.uk/news/article-8801437/Trump-doing-told-Walter-Reed-doctors-walk-today.html

https://www.dailymail.co.uk/health/article-8798533/What-White-House-doctors-treat-Trump-with.html

Arthur Vallejo
@ArthurVallejomd
·
1m
The Type 1 Interferons just like anti-SARS-CoV-2 monoclonal antibodies have to be produced through genetic engineering. They are all very expensive and health insurance companies refuse to pay for them until big randomized, controlled, blinded, placebo-controlled trials published

Arthur Vallejo
@ArthurVallejomd
·
7m
Synairgen produces inhaled interferon 1 beta. The product name is sng001. The White House had priority access to any medicine

President Donald Trump has 'minor' COVID-19 symptoms, has been lethargic and fell asleep on Air Force One on Wednesday night, sources say, but is considering an address to the nation on Friday in an effort to prove to the American people is still fit to lead the country despite being diagnosed with the virus and having to quarantine with First Lady Melania

For the posters that might of missed last nights discussions. GLA

Akiko Iwasaki
https://www.medscape.com/viewarticle/933621#vp_2

Medicine and the Machine from 8.22 mins

Topol: A paper just came out in Nature Reviews Immunology that reviewed four small ongoing trials and that multicenter study from China. All of them look quite promising. If you were to predict the future, do you envision that we all could have an inhaler with an IFN that we would take at first diagnosis or exposure? Do you think that's a possibility?
Iwasaki: As long as we can give the right dose without toxicity, that may be the future, especially in a preventive setting. For example, if your family member was diagnosed with a viral infection, you could potentially treat the rest of the family members with prophylactic IFN, and healthcare workers or people who are exposed to high-dose virus on a daily basis. That's what happened in China; they gave an inhaled IFN to healthcare workers and none of them were infected. So this may be a good thing to do in the future

Posted by Ragz last night..............Worth a repost. So Trump...... can NOW place orders to Clinigen via the speaking to their customer services department.

CLINIGEN Phone call01 Oct 2020 22:31
Late post, but the guy from CLINIGEN called me back this afternoon, and was shocked on how much information he told me.
So just to get to the point, he confirmed that if your a doctor or calling from a hospital and meet Synairgen's requirements. You are able to place an order for the SNG001 treatment! So hospitals can NOW place orders to Clinigen via the speaking to their customer services department. However for the time being, orders can only be placed from EU countries.

Thanks

Ragz

https://uk.reuters.com/article/covid19-ifna2b/interferon-therapy-may-speed-recovery-from-covid-19-idUSL1N2D20Z0

NEW YORK (Reuters Health) - Treatment with the antiviral interferon alfa-2b (IFN-a2b) appears to speed up virus clearance and lower levels of key inflammatory markers in patients with COVID-19, according to an exploratory study conducted in Wuhan, China.

This study provides “the first compelling evidence of a potential treatment that is approved and we have decades of experience with,” Dr. Eleanor Fish of the Toronto General Hospital Research Institute and the University of Toronto Department of Immunology, in Canada, told Reuters Health by phone.

In a paper in Frontiers of Immunology, Dr. Fish and colleagues report the clinical course of 77 adults with confirmed COVID-19 who were treated with inhaled IFN-a2b (5 mU b.i.d), arbidol (200 mg t.i.d) or the combination of both broad-spectrum antivirals. All patients had only moderate illness; none required intensive care or oxygen supplementation or intubation.