Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
Thanks Sandy.
From what I can see they've made some additions to include analysis for long covid (60 and 90 day follow ups).
Going out on a limb here but today marks the final 60th day follow up for the last patient recruited (I.e today all patients have now been followed up for their 60th day follow up but some are still pending their 90th day follow up).
Hopefully Synairgen can now do an interim analysis for all home trial patients for long covid/60th day follow up, add this to their home trial analysis and publish the results soon? 90th day & full long covid results to come afterwards? I'm just guessing here
It was annouced a month ago
-UNI91103 is a nasal spray delivering niclosamide - a potent inhibitor of SARS-CoV-2 with in-vitro potency >40x higher than remdesivir - to the nasal cavity
- UNI91103 has been selected as the first agent to be trialed in a study by UK investigators
prnewswire.co.uk/news-releases/uni91103-developed-by-union-therapeutics-a-s-selected-as-first-agent-for-prophylactic-covid-19-protect-v-study-in-high-risk-patients-895519121.html
Thanks for the update CW25.
You said your parents finished the home trial on the 6th December and have now had their (final?) follow up on 18th March (14 weeks/102 days later).
I'm assuming Synairgen won't be reporting their full home trial analysis of long covid as the last patient recruited (20th Jan + 14 day course) will be due their final follow up in mid May (+ the nurse told you results next month).
linkedin.com/posts/synairgen-research-ltd_small-uk-biotech-firm-aims-high-with-coronavirus-activity-6778262523448705024-hPnp
Correct link
Who has access?
linkedin.com/posts/synairgen-research-ltd_small-uk-biotech-firm-aims-high-with-coronavirus-activity-6778262523448
I missed it the first time but 2:14 - 2:42 Prof Holgate confirms activ 2...
Posting my post off advfn purely to take the attention away from the negative posters...
Just some ramblings but I have been thinking about what could take sng's target price closer to numis's upper targets 5000p as opposed to 990p in terms of trial results.
If phase 3 has similar results to phase 2 (statistically significant reduction in likelyhood of progression to severe disease or death and more likely to recover to OSCI scale of 1 within 15/16 days vs placebo) then there's 3 other things the trials could show to elevate the worth of sng:
1) Home trial shows statistical significance in preventing hospitalisation
This would increase the total addressable market (TAM) 10 fold. Anyone diagnosed with covid that is 65+ or 50 with a condition would be sent sng. I don't have exact figures but if 2 in 10 of this "at risk" population goes onto becoming hospitalised, it would still be cheaper to treat all 10 with sng and prevent those 2 hospitalisations.
2) SNG shows a large reduction in mortality
Dexamethasone - the only other approved covid treatment that has shown to reduce deaths - does so by 17%. If phase 3 shows something larger than dexamethasone it will cement the fact it should be purchased and rolled out globally. Just as an example, if in the phase 3 trial, out of 300 placebo patients 20 die and out of the sng group of 300, 16 die then that's a 20% reduction... that doesn't seem too absurd if it already statistical significantly reduces progression of disease.
Going even further if you times the phase 2 trial results by 6x then the 100 trial size becomes 600, the 3 placebo deaths becomes 18 and the sng group is still 0 (100% reduction ??.. one can dream).
3) If SNG shows to reduce the incidence of long covid
It will be the ONLY drug globally to show this. No other drug as far as I'm aware is even being investigated to reduce the incidence of this. Here's the important bit - even mild cases of covid in a 20 year old can have debilitating and lasting effects (long covid). From the news last week "Two Newcastle United players are suffering from the “brutal” long-term effects of Covid-19, with Steve Bruce admitting there is no timescale on when they will be able to return to action. In a stark warning about the danger of the virus to young people..."
If sng shows to be useful against long covid then again - the TAM is increased substantially. Maybe not on the NHS, but it will be sought after through private medical in the US or something celebrities/rich people will get through their private doctors if they get covid.
Thoughts welcome
Oh my goodness i have been visiting different care homes on a weekly basis.. I need to get some damn posters!! Anyone know an email address contact for synairgen? Nothing on there website only consillium contacts
@Pharma123
Who exactly did you contact to get these? I will make contact to get some and stick them up around my hospital, some community clinics and give some to the research nurse
You're very far from the truth if you think theres no treatment for hospitalised covid patients.
Titrated on oxygen (0.5-15L) depending on sats. Started on dex/remdesivir and/or recruited onto recovery for convalescent plasma/azithromycin or whatevers going at the time.
Co morbidities managed - diabetes, heart failure, copd/astma, dementia etc. Theyre not eating - nutrition needs need to be managed. Not going toliet/constipated/retaining urine that needs sorting. Bloods and blood gases need doing regularly. Are they end of life or approaching? Need to make that decision which isnt easy and start them of end of life medications to ease their suffering etc etc all this when its a weekend and cover is low staff are going off sick and the wards are full of 70/80 year olds with diabetes heart failure and dementia all at the same time
@110times
What exactly is your agenda? 1/3 of the beds in my hospital are filled with covid patients. That's double the first wave. This weekend i didn't have time to provide adequate standard of care for the patients on my list because of the number of patients that became acutely unwell. We are that snowed under. Im at a Midlands hospital.
Unfortunately you cannot as i don't want any gmc issues.. Emailled clinigen from my work email the day of the announcement but couldnt get any useful info out of them.. Just registration forms requiring consultant signatures etc
Only thing they did say is that funding would typically come out of hospital/departmental funding.
@dumbpunter the NHS site is technically correct. I think what the public and what the nhs defines as severe covid is different. Every patient that is admitted into hospital with covid is considered moderate-severe. Mild cases aren't admitted.
Anyone desaturating below 94% / shortness of breath /difficulty breathing comes in, gets oxygen and is put on dex
Dex is pretty much given to all patients that are hospitalised with covid along with oxygen in the UK.. Take it from someone who just finished a weekend on the respiratory ward... Its not restricted for just the seriously ill
Sorry interferon kappa* not gamma... which i havent come across before
Just stumbled upon this using pmjh's patented search method (synairgen OR sng001 OR sng016 OR "interferon beta" OR "interferon beta 1a" OR ifn-ß OR ifn-ß-1b OR NCT01126177 OR NCT04385095 OR 2020-001023-14)
Published in the lancet today it showed positive results... + a chinese competitor (However i believe Interferon Beta is superior to gamma?)
An open-label, randomized trial of the combination of IFN-? plus TFF2 with standard care in the treatment of patients with moderate COVID-19
hTTps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30291-1/fulltext
I know the company said it wasnt adversely affected by covid in the june update but just reading this article and interested in your opinions
https://asia.nikkei.com/Economy/Malaysian-GDP-plunge-fuels-talk-of-post-COVID-economic-remodeling
Malaysia's central bank last week announced that gross domestic product plummeted 17.1% in the April-June period, well below expectations and far worse than regional peers. The result -- largely attributable to a sharp drop-off in private sector spending and exports, as supply chains were slammed by the crisis -- prompted Malaysia to lower its official estimate for the full year to a contraction between 3.5% and 5.5%.
To control COVID-19, the country had imposed some of the strictest social distancing rules with its movement control order, resulting in hundreds of millions of dollars in lost daily output. But after a gradual reopening began in May, the economy is expected to pick up from the third quarter, backed by government stimulus.
Is there not a chance the results could not be what we are hoping for? or the fact that mobile/bill payments make up the bulk of revenue, are we assuming they will be unaffected by covid? And have continued to increase?
Johnht has absolutely lost his nut.
I started a discussion on peer review last night and just because of my username he thinks people are ramping that share? You need to stop posting mate
Anyway to change the subject I can see alot of similarities between Immunomedics and Synairgen and maybe a clue to our future.
- Immunomedics (IMMU) have never brought a drug to market
- had one promising patented breast cancer drug in development but it was theorized to be effective against multiple other cancers (SNG effective vs covid but with scope for use in copd exacerbations or flu/colds etc)
- Back in April IMMU shares were trading at $9
- they recieved Accelerated approval based off ONE PHASE 2 STUDY involving 108 patients in April (full approval was to be granted after a phase 3 study)
- share price rose to ~$20s and continued climbing to $44 on speculation of a takeover over the next 4 months
- Bought by Gilead for $90 a share/$21 billion
Thats a 10x increase in 5 months and something that could happen to SNG from now (pre-approval) to T/O or Partnership
Im not that idiot parsley, ive filtered him.
Enough of this board has been taken up with his drivel today.
Its very difficult for governments/scientists/media to get behind scientific breakthroughs unless the data is peer reviewed and published in a journal.
Until that happens i can understand why sng has not been publicized more. Imagine being a renowned scientist or media organisation putting out articles about a breakthrough drug thats only had market data released and profitted 400%... And then when it actually is published & peer reviewed its a load of tosh, that would look very bad.
Dont get me wrong I'm all eggs in one basket with sng, have a sizeable investment and 100% confidence, but RM needs to get this peer review out there!!! Its coming up to 8 weeks now