Question25 Apr 2018 06:39
Is the amount of work we are doing with antibodies beyond the norm of existing treatments on the market??
Advances in understanding the pattern of sugars (glycans) that adorn cells have highlighted important differences between those on tumour cells versus their normal counterparts. This altered sugar signature of tumour cells is intricately linked to the majority of cancer cell biology hallmarks. Antibodies that target such tumour glycan signatures, when coupled to a novel approach to invoke an immune response on binding, provide an attractive strategy for immunotherapy and forms the basis of the platform technology developed by Prof. Lindy Durrant and her team at the Nottingham University Therapeutic Antibody Centre (NUTAC).1