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China’s CanSino Biologics has released results from the Phase I trial of its Covid-19 vaccine — data that have propelled its entry into Phase II more than a month ago.
In a paper published in the Lancet, the biotech reported that their adenovirus-based vaccine was “tolerable and immunogenic at 28 days post-vaccination” among the 195 volunteers enrolled in the trial. In addition to antibody responses, T cell responses were also observed.
“Humoral responses against SARS-CoV-2 peaked at day 28 post-vaccination in healthy adults, and rapid specific T-cell responses were noted from day 14 post-vaccination,” the researchers wrote.
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The most common adverse reactions were fever, fatigue, headache and muscle pain.
The publication followed a promising snapshot from Moderna on its mRNA vaccine candidate, although the US biotech didn’t break down the numbers.
Like Moderna, CanSino has dropped the highest dose and will be comparing the low and middle doses with placebo in Phase II. People over the age of 60, who weren’t eligible for the first-in-human study, were also enrolled.
The CanSino candidate employs a recombinant adenovirus type-5 (Ad5) vector to encapsulate a SARS-CoV-2 spike glycoprotein to elicit an immune response — a technology they’ve previously used to develop an Ebola vaccine.
Toward the end of what otherwise reads like a usual scientific paper, the scientists made note of the urgency their work carries:
Many vaccine candidates are in rapid development, including recombinant-protein based vaccines, replicating or non-replicating viral vector-based vaccines, DNA vaccines, and mRNA vaccines (which mostly have focused on the spike glycoprotein or receptor binding domain), live attenuated vaccines, and inactivated virus vaccines. All of these vaccine platforms have advantages and disadvantages, and it is too soon to predict which will be more successful.
The study was conducted in Wuhan, ground zero of the global pandemic, in March and April.
I was wondering, that as sierra have not got a bean to progress our sra737 , if sareum/icr and cruk have approached our Chinese partner to take over sra737 . I would be disappointed if they have not. . good day today. stay safe .
a nice video from cdc in china about a vaccine by September . video is from april this year.
https://youtu.be/gMINUvYr4EA
that didn't work so here is the article.
Trump advisor Navarro asserts China is withholding data to win vaccine race
On Sunday, White House advisor Peter Navarro took to Fox News to accuse China of taking a suite of actions to worsen the ongoing coronavirus crisis.
“First of all, the virus was spawned in China. Second of all, they hid the virus behind the shield of the World Health Organization. The third thing they did was basically hoard personal protective equipment and now they’re profiteering from it,” Navarro said on Fox News program Sunday Morning Futures.
The outspoken critic of China, who has been tasked by President Trump to work on supply issues relating to the pandemic, on Monday suggested on Fox News that the country is withholding data about early coronavirus infections in order to be the first to develop a vaccine.
“One of the reasons that they may not have let us in and given us the data on this virus early, is they’re racing to get a vaccine and they think this is just a competitive business race, it’s a business proposition so that they can sell the vaccines to the world,” he said.
The race to develop a vaccine has heated up, with China’s CanSino as one of a handful of developers with a vaccine in human testing. — Natalie Grover
Society needs to pitch in to shore up drug, vaccine manufacturing; Trump advisor Navarro suggests China is withholding data to win vaccine race ?
interesting article , click on link then scroll down to article about Navarro , suggesting that china has info on virus and is keeping it quite to produce a vaccine or treatment to make a fortune.
my brother has a friend who lives in Moscow, married to a Russian woman with links to fsb. this backs up the word on the street in Moscow. I was surprised that covid 19 had the same infection mechanism as hiv when the virus came out , as at the time it suggested that that could only happen in a lab and had to be spliced on to an existing virus. what a sad world. I hate socialism , right wing and left wing Nazis are just as bad as each other . lets hope for a cure soon .
at the moment the earth has changed its orbit and is closer to the sun , but thankfully the sun has few sun spot activity so is less hot , the earths magnetic field has weakened as the poles start to shift , magnetic north is in Siberia , and will eventually shift so north becomes south and south becomes north , due to a weakened magnetic field the earth is being subjected to more intense solar radiation which is affecting the upper atmosphere which with a shift in the earths tilt which has already happened is causing the jet stream to shift south pushing storms and thus wetter weather , violent storms being brought up from the equator affecting the northern hemispheres weather . the increase in solar radiation is also affecting the earths crust so more earthquakes and volcanic activity . hab has already started, our concern should be global cooling / ice age . one day 70 million English will thunder back in to north Africa looking for a place to live. probable why they prefer to keep the public in the dark .
is your calc just for Saudi or worldwide.
Signing of New Drilling Contract www.investegate.co.uk/article.aspx?id=201705300700114788G&fe=1
so sad to hear that ken has passed on . my condolences to his family at this difficult time. rest in peace my friend.