Member Info for Borsaci06

Jwd222

Grant of options @ 1p covers for both 10p & 300p
RNS Number : 4363Q
RNS Number : 9515A

@AlionderCPC

ILC1s demonstrate memory responses and contribute to trained immunity.
Increased numbers of circulating ILC1s correlates with disease severity and exacerbation in many chronic diseases like in the lung during #COPD pathogenesis
https://twitter.com/AlionderCPC/status/1421044468032102401

" The lung epithelium and also liver hepatocytes are targets of SARS-CoV-2 infection and overshooting immune responses can trigger both severe lung and liver damage. ILC1s may contribute to the early defense against viral infection but also to the pathogenesis of immunemediated tissue damage. In combination with systemic in?ammation as a fuel for liver injury in COVID-19 patients, local autoenhancement of ILC1 generation and cytokine expression may contribute to both liver and lung damage. "
Thomas M. Conlon, Percy A. Knolle and Ali Önder Yildirim
Published 29 July 2021

https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/

"Everyone with severe COVID-19 had a blunted interferon response early on in their epithelial cells and were never able to ramp up a defense." Says @ordovas_phd
https://www.biotechniques.com/covid-19/sniffing-out-the-source-influencing-covid-19-severity/

" 20 more vaccinations to go "
https://twitter.com/favourafolabi/status/1420864201191477248

p4
Increasing percentage of vaccinated persons among those hospitalized in COVID-NET
https://context-cdn.washingtonpost.com/notes/prod/default/documents/54f57708-a529-4a33-9a44-b66d719070d9/note/753667d6-8c61-495f-b669-5308f2827155.#page=1

Items reviewed by the DSMB include:

* Interim/cumulative data for evidence of study-related adverse events;
* Interim/cumulative data for evidence of efficacy according to pre-established statistical guidelines, if appropriate;
* Data quality, completeness, and timeliness;

* Performance of individual centers;
* Adequacy of compliance with goals for recruitment and retention, including those related to the participation of women and minorities;
* Adherence to the protocol;
* Factors that might affect the study outcome or compromise the confidentiality of the trial data (such as protocol violations, unmasking, etc.); and,
* Factors external to the study such as scientific or therapeutic developments that may impact participant safety or the ethics of the study.
https://www.nidcr.nih.gov/research/human-subjects-research/toolkit-and-education-materials/interventional-studies/data-and-safety-monitoring-board-guidelines
https://www.ctti-clinicaltrials.org/files/recommendations/dmc-recommendations.pdf

some copies still there
https://thedailydan.tumblr.com/post/657994405473632256/yesterday-nbc-news-correspondent-ken-dilanian

" It has been found that about 3.5% of COVID-19 patients had known
autosomal-recessive (AR) deficiencies [interferon regulatory factor 7 (IRF7) and IFNAR1] and
autosomal-dominant deficiencies (AD) [toll-like receptor 3 (TLR3), UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, and IFNAR2]. These findings suggested important roles of not only IRF3 or IRF7 but also TLR3 in the control of SARS-CoV-2 infection "

Farooq Rashid1, Muhammad Suleman, Abdullah Shah, Emmanuel Enoch Dzakah, Haiying Wang, Shuyi Chen and
Shixing Tang
16 July 2021

good read here with visual

https://www.nature.com/articles/d41586-021-02039-y
" And this June, researchers reported mutations in the Alpha variant that seem to enable it to subdue interferon production even more efficiently "
" a study reported that the Delta variant grew more rapidly and at higher levels inside people’s lungs and throats than did earlier versions of the virus "
28 July 2021
Megan Scudellari

30 month contract for £3.185 billion being tendered by Govt to sort blood clots.
https://www.contractsfinder.service.gov.uk/notice/bbec3a9a-168a-46c5-a71d-990c2a8a8212?origin=SearchResults&p=1

“Further, it suggests that there may be a clinical window in which severe disease can be subverted by focusing preventative or therapeutic interventions early within the nasopharynx bolstering anti-viral responses and curbing pathological inflammatory signaling prior to development of severe respiratory dysfunction or systemic disease.”
https://www.contagionlive.com/view/response-to-covid-19-in-nasopharynx-may-determine-disease-severity

CDC warns COVID-19 may be a few mutations away from evading vaccines
https://nypost.com/2021/07/27/cdc-covid-19-may-be-a-few-mutations-away-from-evading-vaccines/?utm_campaign=SocialFlow&utm_medium=SocialFlow&utm_source=NYPTwitter

" the agreement that countries had with Pfizer does not allow them to escape their contract, which states that even if a drug will be found to treat COVID19 the contract cannot be voided. "

https://twitter.com/eh_den/status/1419659586936713221
@eh_den claims to have copy of Pfizer contract with one country

" enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN ß monotherapy against COVID-19. "
2021 Jul 23
Suresh Kumar Kali, Peter Dröge, Priyatharshini Murugan
https://pubmed.ncbi.nlm.nih.gov/34311016/

"Everyone with severe COVID-19 had a blunted interferon response early on in their epithelial cells, and were never able to ramp up a defence," said Ordovas-Montanes.

"Having the right amount of interferon at the right time could be at the crux of dealing with SARS-CoV-2 and other viruses."
https://www.ctvnews.ca/health/coronavirus/study-suggests-people-who-develop-severe-covid-19-have-blunted-antiviral-responses-in-the-nose-throat-1.5521329
Nicole Bogart
CTVNews.ca Writer
@nlynnbogart
Published Friday, July 23, 2021 6:20PM EDT

" SARS-CoV-2 rewires host chromatin architecture to confer immunological gene deregulation and to weaken interferon response genes "
July 21, 2021
https://www.biorxiv.org/content/10.1101/2021.07.20.453146v1.full.pdf

when this is published poeple over look at SNG, only interesting on Covid 19 Trials.

Synairgen is on that list because it covers
4 Disease Category
10 Diseases

* 4 Disease Category
Bacterial and Fungal Diseases
Immune System Diseases
Respiratory Tract (Lung and Bronchial) Diseases
Symptoms and General Pathology

* 10 Disease
Asthma
Bronchial Diseases Hypersensitivity
Hypersensitivity, Immediate
Lung Diseases
Lung Diseases, Obstructive
Respiratory Aspiration
Respiratory Hypersensitivity
Respiratory Tract Diseases
Virus Diseases

Life, Liberty & Texas
@redrivercrafts1
Replying to
@ChuckCallesto
Harris went to Walter Reed for a conveniently "routine" covid test & "routine" Interferon infusion...per WH press release. How timely. Who gets routine Interferon infusions anyway???
4:32 PM · Jul 20, 2021
https://twitter.com/redrivercrafts1/status/1417507832895885312

same thing said for Trump,
never denied or accepted