RE: Probably a nothing burger...13 Aug 2024 21:16
Think it says this: (translated in Notes)
We have summarised the information on their site about Scancell's GlyMab platform.
Scancell has developed a new technology that generates mAb that recognises changes in sugar chain modifications known as "glycome" in cells with high specificity. This sugar chain modification can be said to be a lot of attractive targets because many cells change dramatically in the process of malignant conversion.
GlyMab platform
In conventional anti-glycan antibody production technology, there was a problem of low target affinity and lack of specificity, but the GlyMab platform succeeded in technological innovation to overcome it.
The possibility of developing various products
Glycan targeted antibodies can be developed into multiple products with different mechanisms of action. For example:
-Dearing powerful drugs as ADCs
-As a double-specific antibody
-Binding domain is used for chimeric antigen receptor (CAR) cell therapy
Portfolio and ongoing research
Scancell has a portfolio of anti-glycan antibodies with very high specificity and affinity for the target. The current portfolio includes 4 mAbs that directly target different glycans on tumour cells and mAb, which is a checkpoint inhibitor. These 5 mAbs are under preclinical evaluation, and the target verification of other mAbs is also underway. This will add new mAbs to the growing portfolio.