RE: Why has Scancell spent more money on Covidity?30 May 2023 19:25
Johnny,
Not easy at all and your efforts are appreciated!
It's impossible to know which updates (if any) were at the suggestion of the reviewers, which were simply an inclusion of work already planned/underway and which were instigated due to developments in the wider field. However, perhaps this new paragraph from the discussion section gives some indication of the rationale behind the additional research on rats:-
'In comparison to the ZyCov-D and INO-4800 vaccines encoding the S protein, the data described herein demonstrate stronger antibody (IgG end point and neutralisation titres) and T cell responses from a 10-100 times lower DNA dose in mouse models 49,66. However, it is difficult to directly compare data as this report details the delivery of DNA using the gene gun and not direct needle injection or electroporation. However, our unpublished data in rats with DNA delivery via a needle-free device compares favourably with similar delivery and dose of the ZyCoV-D data in rabbits showing higher antibody titres and T cell responses.'
ZyCov-D was the world's first DNA vaccine to be approved for covid and INO-4800 is Inovio's DNA covid vax and thanks to the new research using a needle free device rather than a gene gun, Scancell are now able to directly compare Covidity to other DNA covid vaccines.
Finally, without more information, I'm not sure we can read too much into the involvement of Texas Biomedical Research Institute. They are world leaders in developing covid animal models and it may simply have been quicker and more efficient to use them rather than carry out the work in house.
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