Spike vs N Detection (I know, not again…)4 Jul 2021 09:59
https://www.biosure.co.uk/tests/covid-19-antigen-test/
Interesting to read the blurb on the Vatic test in terms of Spike vs N protein detection. It’s a very dumbed down, direct swipe at N detection, favouring Spike as a live, more prevalent part of the virus.
“The proprietary Know Now® test, detects the spike protein to the virus (not the nucleocapsid protein as with all other lateral flow antigen tests) and this spike is only apparent on live virus, therefore the test only identifies those people with current infection. It is a true infectivity test.”
Also describes LoD as a more appropriate measure of sensitivity, exclaiming that 500pfu/ml is the standard for asymptomatic testing.
“Independent data evidences the Know Now™ test can detect as low as 500 pfu/ml, which basically means it should show a positive result for someone with COVID-19 the day before they become infectious to someone else.”
Incidentally, our test is 100% sensitive for asymptomatics. With this 500pfu/ml reading across to our test performance of 50pg/ml, as confirmed in the business update;
“ How does this analytical sensitivity translate into pfu/ml of virus which is the clinically relevant measure? Avacta has established this relationship using Avacta’s research ELISA for S1 protein and inactivated virus provided by Public Health England (Porton Down, UK). Using this safe form of the virus, we have shown that an analytical LOD of 50pg/ml corresponds to the amount of S1 spike protein in a virus sample containing 500 pfu/ml.”
Interesting, simple take for others that are interested. Might be biased marketing, it seems to offer some sense.
Sign In
Follow the stocks
