UPDATE 2-FTSE 100 snaps 4-day losing streak on vaccine hopes

* UK says Brexit talks are over unless EU changes course

* J D Wetherspoon slips on annual loss, job cuts

* Jupiter Fund tumbles on higher quarterly net outflows

* FTSE 100 up 1.5%, FTSE 250 falls 0.1%
(Updates to close, adds comments)

By Devik Jain

Oct 16 (Reuters) - The FTSE 100 snapped a four-day losing
streak on Friday after an upbeat coronavirus vaccine update from
Pfizer and signs Brexit talks might continue until the year end
for a possible trade deal with the European Union.

Drugmaker Pfizer Inc said it could file for U.S.
authorisation of the COVID-19 vaccine it is developing with
German partner BioNTech as early as late November.

The blue-chip index closed up 1.5%, led by
pharmaceutical, aero, bank
and insurance stocks.

However, the FTSE 100 and the mid-cap index logged their
first weekly declines in three weeks on concerns that the new
tiered coronavirus restrictions across parts of England would
derail a nascent economic recovery.

"With more than half of the country under 'high'
restrictions, it's hard not to discount the possibility of even
tighter restrictions over the winter months," wrote Deutsche
Bank economist Sanjay Raja in a note.

"Despite the relatively modest increase in restrictions
nationally, constraints on activity will almost certainly derail
the UK's economic recovery."

Prime Minister Boris Johnson asked businesses to prepare for
a no-trade deal Brexit unless the EU fundamentally changed
course.

The mid-cap FTSE 250 index ended 0.1% lower as J D
Wetherspoon Plc tumbled 19.4% after the pub operator
posted an annual loss and announced job cuts as it called for
"sensible" government measures to contain the health crisis.

Jupiter Fund Management Plc shed 3.3% after the
asset manager suffered one billion pounds in net outflows in the
third quarter.

Shares of oil major BP Plc rose 1.4% after falling to
their lowest level since 1995 in the previous session.

Luxury goods maker Burberry Group Plc jumped 3.2%
after the world's biggest luxury goods group, LVMH,
said recovering sales of Louis Vuitton handbags had helped it
contain the fallout from the pandemic in the third quarter.
(Reporting by Devik Jain in Bengaluru; editing by Uttaresh.V
and Elaine Hardcastle)