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Amryt Pharma reverses onto AIM to advance orphan drug strategy

Tue, 19th Apr 2016 12:05

(ShareCast News) - Speciality drug developer Amryt Pharma has completed its flotation via the reverse takeover of AIM-listed Fastnet, raising £10m of new cash in the process and acquiring two operating companies.As part of the float, Amryt acquired drug German drug development and manufacturing company Birken and Swiss-US biotech SomPharmaceuticals, both of which are focused on potential drugs for rare, or 'orphan', conditions.Shore Capital is the company's nominated adviser and joint broker, with Dublin-based Davy joint broker, while Stifel acted as co-lead manager on the fundraising.Amryt, which completed an eight-for-one share consolidation ahead of the float, said the placing proceeds to accelerate the development of Birken's Episalvan, a treatment for epidermolysis bullosa (EB), a rare genetic skin disorder and orphan condition that typically affects young children and for which there is currently no approved therapy.Episalvan, which is already approved in Europe as a treatment in adults for accelerated healing of partial thickness wounds following three successful phase III studies, has been awarded Orphan Drug Designation in the US and EU for EB after successfully completing a Phase IIa study in ten EB patients.Chief executive Joe Wiley, a neurologist-turned-private equity man is backed by an experienced executive and non-executive board, said Amryt's strategy was to build "a portfolio of differentiated medicines, in therapeutic areas where there is a large unmet medical need and which offer significant commercial potential".Wiley intends to use the new funds to progress a Phase III clinical trial of Episalvan in the second half of the year with a view to obtaining a label extension to include approval for the treatment of EB in Europe and the US. Directors estimate the global EB market is worth roughly $1.5bn per year.Birken is already generating revenue from sales of its Imlan range of derma-cosmetics, which contain the same active ingredient as Episalvan but are focused on alleviating symptoms associated with dry and irritated skin such as eczema, psoriasis, atopic dermatitis, as well as treating damaged skin barriers and allergy prone skins.Further cash will be required to enable the group to exploit its other assets, the admission document also said, notably Episalvan for other wound types, together with Som's pre-clinical assets focused on Acromegaly and Cushing's disease.Shares in Amryt reached 25p on Tuesday, up more than 4% from the 24p placing price.
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Amryt Pharma granted another two US patents

(Sharecast News) - Commercial-stage biopharmaceutical company Amryt Pharma updated the market on patents for its lead development candidate 'Oleogel-S10' on Tuesday, as well as its recently-acquired and third commercial product 'Mycapssa'.

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IN BRIEF: Amryt Pharma ups guidance again after Chiasma acquisition

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IN BRIEF: Amryt hikes guidance on record second quarter results

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Record second quarter sees Amryt lift guidance further

(Sharecast News) - Amryt Pharma reported record second quarter results on Friday, raising its full-year guidance, as revenue in the three months ended 30 June came in at $62.8m, up from $46.2m year-on-year.

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29 Jul 2021 17:10

EXECUTIVE CHANGES: HL CFO to depart; Novacyt hires CEO from Amryt

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3 Jun 2021 19:20

BUSINESS UPDATES: HSBC issues notes; discoverIE reports profit fall

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3 Jun 2021 11:26

FDA grants Amryt's Oleogel-S10 priority review status

(Sharecast News) - Commercial-stage biopharmaceutical company Amryt Pharma announced on Thursday that the United States Food and Drug Administration (FDA) has granted priority review status for the new drug application for 'Oleogel-S10', for the treatment of epidermolysis bullosa (EB).

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Amryt completes rolling FDA submission for Oleogel-S10

(Sharecast News) - Commercial-stage biopharmaceutical company Amryt Pharma has completed the rolling submission of a new drug application (NDA) to the US Food and Drug Administration (FDA) for 'Oleogel-S10', it announced on Wednesday, for the potential treatment of cutaneous manifestations of junctional and dystrophic epidermolysis bullosa (EB).

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