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toot
these are US based, B2B suppliers
https://believepharmaceutical.com/cardiovascular
Capsules with WSTC II (Fruitflow®), vitamin C, pomegranate extract and vitamin E.
believepharmaceutical.com was first indexed by Google in December 2021
The FF combo looks familiar but can't track down the retail product
W$
Thing is, the only snippets of anything right now are coming from China. I don't think anyone has forgotten about the rest of the world or the PXS DSM negotiations for the new agreement but until there is something to post...........
Looks as though everyone has placed all the hope on China, of course it is a huge market and to do well there would be massive, but have we given up elsewhere, sales must be improving in the markets we are already active.
When China SAMR approval is in place and large orders are in the bag.
All these articles are fantastic ,but when will we see the sp reflect this
Another
A masterpiece of tomato! Sun Yat-Sen University Experiment: Water-soluble Tomato Concentrate Can Help Cardiovascular Health.
https://www-163-com.translate.goog/dy/article/H9019DDS0552QWC0.html?_x_tr_sl=zh-CN&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp
The funding is also v.interesting.
This work was supported by the National Natural Science Foundation of China (Nos. 82030098, 81872617, and 81730090), Shenzhen Science, Technology, and Innovation Commission (No. JCYJ20180307153228190), By-health Research Foundation and Scientific Research Foundation of Chinese Nutrition Society – DSM Scientific Research Foundation (No. 5800071020001). The funders did not participate in the design, data collection, data analysis, interpretation of the clinical trial, and the writing of this manuscript.
Slam, This is what By-Health say about the intellectual property regarding Fruitflow.
"(2) During the period of the drug research and development agreement, Provexis and the company will cooperate in drug research and development projects according to the terms of this agreement, and the company has the exclusive right to research and development of drugs in the agreement area. (3) With regard to intellectual property rights, each party shall at all times be the owner of all knowledge owned by each party prior to entering into this Agreement or independently created outside the scope of this Agreement (“Background Intellectual Property Rights”); further, this Agreement The implementation of this will not result in the transfer of background intellectual property rights by either party to the other."
https://data-eastmoney-com.translate.goog/notices/detail/300146/AN202111051527225504.html?_x_tr_sch=http&_x_tr_sl=zh-CN&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp
By Health are funding an awful lot of studies on the differing effects of WSTE, and Some of these studies would appear to be pushing the use of WTSE into mainstream medicine too.
I sometimes wonder who will own the IP rights for some of these results. I am not sure that it matters too much as Provexis do own the parent IP.
Whatever way it turns out, BH are certainly pushing the awareness of WTSE (at least to the Chinese population and that can only be good for us in the long (or even medium) term.
"secondary prevention of WTE on individuals with metabolic diseases merits further clinical study."
And then there is this.
"Water-soluble tomato extract improves platelet function in subjects with metabolic syndrome: a randomized clinical trial"
Source(s) of funding: BY-HEAITH CO.,LTD
Target disease: metabolic syndrome
Study execute time: From2020-12-01To 2022-12-31
Objectives of Study:
"Metabolic syndrome induced platelet hyper-activation and hyper-aggregation, which plays an important role in the pathological process of CVD. Water-soluble tomato extract can inhibit platelet activation and aggregation in vitro and in healthy adult. However, the effect of water-soluble tomato extract on platelet function in subjects with metabolic syndrome are unclear. The present study intends to investigate the effect of water-soluble tomato extract on platelet function and dose-response in individual with metabolic syndrome."
http://www.chictr.org.cn/showprojen.aspx?proj=64530
Following on from the Conclusion that DP64 posted. A couple of bits that caught my attention.
Primary prevention.
"This evidence indicated that daily intake of WTE is safe in Chinese healthy middle-aged and older individuals, and it has the potential to be applied for primary prevention of CVDs."
Secondary Prevention.
"The findings of our study which focused on Chinese healthy middle-aged and older individuals just indicate a potential benefit for primary prevention of CVDs in Chinese healthy middle-aged and older individuals, and the primary or secondary prevention of WTE on individuals with metabolic diseases merits further clinical study."
Many thanks gixer.
DP64, the last RNS a couple of days ago on the 31st tells us that five are completed.
Hi gixer,
As you are following very closely about the By Health development. So out of 8/9 study they need for SAMR approval how many they have completed? I believe all these are part of that study. Any thoughts about it will be very much appreciated.
Many of us ,have been there since 2009
This one, funded by By-Health, was due to be completed by 30-05-2022
"A human subject research: the effect of By-health Fruitflow tablets on platelet aggregation"
Lets hope there were no major delays due to lockdowns in Beijing.
http://www.chictr.org.cn/showprojen.aspx?proj=129186
So the conclusion is very good then.
============================
Conclusion
In summary, 150 mg WTE per day for 4-week supplementation can significantly inhibit platelet activation, aggregation, and granule secretion in Chinese healthy middle-aged and older individuals, and the effect of 4-week WTE is safe. After 2-week washout period, the inhibitory effect of 4-week WTE supplementation on platelet function can be eliminated. This study provides novel evidence to support the importance of WTE as a protective food supplementary for early prevention of CVDs in Chinese healthy middle-aged and older individuals.
Now published.
01 June 2022
"Four-Week Supplementation of Water-Soluble Tomato Extract Attenuates Platelet Function in Chinese Healthy Middle-Aged and Older Individuals: A Randomized, Double-Blinded, and Crossover Clinical Trial"
https://www.frontiersin.org/articles/10.3389/fnut.2022.891241/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE
Yes, been here since then
Actually that occurred in 2009, so 13 years ago
Anyone been in this as long as me. Remember the Coca-Cola it went from 1p to 22p. 11 years In been in this
By-Health institute of nutrition and health.
From yesterday.
"Stroke is associated with abnormal platelet aggregation, do aspirin and water-soluble tomato concentrate help?"
https://www-toutiao-com.translate.goog/article/7103773780329103912/?log_from=cf2ef575c0908_1654086137615&_x_tr_sl=zh-CN&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp&wid=1654086503818
"In 2017, as more clinical studies of water-soluble tomato concentrate came out, some scientists reviewed it again, further demonstrating its safety and effectiveness, and they believed that water-soluble tomato concentrate could help susceptible heart disease. Primary prevention of vascular disease population, showing the potential to prevent cardiovascular disease."
Why such a huge difference between buy and sell