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Truthcaller thanks for sharing your research at least some realise the value behind today's rerating....a Sleeping giant as it was for the last month
Just like watching the movie "Titanic".
Lumsden is safely floating away in the first class lifeboat and the gullible private investors clinging to small pieces of flotsom!
Moneymunch great analysis...thanks for sharing, a multiple rerating..once in a life time opportunity..imo
Motif Bio (MTFB) fundamentals
Motif Bio plc is a clinical-stage biopharmaceutical company focused on developing novel antibiotics designed to be effective against serious and life-threatening infections caused by multi-drug resistant Gram-positive bacteria, including MRSA. The Company's lead product candidate is iclaprim. Motif Bio is seeking approval of iclaprim from the U.S. Food & Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI). More than 3.6 million patients with ABSSSI are hospitalised annually in the U.S. It is estimated that up to 26% of hospitalized ABSSSI patients have renal impairment. The Company also has plans to develop iclaprim for hospital acquired bacterial pneumonia (HABP), including ventilator associated bacterial pneumonia (VABP), as there is a high unmet need for new therapies in this indication.
Should support the rise ?
Dr Nik Hirani, Reader in Respiratory Medicine and Associate Medical Director in Lothian and Former chair of NICE Thoracic Interstitial Lung Disease guideline committee, said: "Lamellar has very convincing data demonstrating strong in-vivo efficacy for Lamellasome formulations in a model relevant to pneumonitis, lung injury and ARDS. I have been following the development of LAMELLASOME™ technology and its development as a respiratory therapeutic over the past few years, and I believe it has real potential to manage the inflammatory respiratory symptoms seen in patients infected with SARS-CoV2."
hTtps://www.ptcommunity.com/wire/lamellar-biomedical-launches-program-designed-prevent-severe-respiratory-effects-covid-19-using
6/6/19
"We continue to believe that iclaprim has the potential to be an important new treatment option for hospitalised patients with ABSSSI and potentially also in patients with hospital-acquired bacterial pneumonia, including ventilator-associated bacterial pneumonia. In addition, we are exploring the use of iclaprim in other disease areas, including orphan indications such as Staphylococcus aureus lung infections in patients with cystic fibrosis and in ophthalmology, as evidenced by recently announced collaborative agreements.
8/4/20
Lamellar Biomedical Launches Program Designed to Prevent the Severe Respiratory Effects of COVID-19, Using its Unique LAMELLASOME™ Technology
....................
A LAMELLASOME™ nebulised treatment used at the early stages of COVID-19, in hospital or the community, could reduce the damaging and often fatal inflammatory response known as Acute Respiratory Distress Syndrome (ARDS) seen in patients. This early intervention has the potential to inhibit fibroproliferative changes during ARDS, markedly reducing severity, mortality and lowering the significant burden placed on the healthcare system.
The time between onset of symptoms of SARS-CoV2 infection and progression to more severe clinical manifestations of COVID-19 such as viral pneumonia and ARDS, is thought to be between 5 – 8 days. Inhaled LAMELLASOME™ treatment administered during this period has the potential to halt or reduce the severity of the disease progression of COVID-19 patients to requiring scarce critical care resource.
Lamellar has strong pre-clinical evidence of inhaled LAMELLASOME™'s protective nature. In a large animal in-vivo model of radiation-induced lung injury, designed to replicate the pathology found in the injured lung, which is representative of COVID-19 patient pathology, inhaled LAMELLASOME™ treatment protected lung cells and tissues from injury, pneumonitis and fibroproliferation/fibrosis at the alveolar/capillary membrane.
Dr Duncan Moore, Chairman of Lamellar, said: "In the past few weeks we have seen the terrible consequences COVID-19 can have on the respiratory function, particularly on vulnerable patient populations. We believe that that the inherent attributes of LAMELLASOME™ are extremely well suited to be a potential approach to preventing the onset of the serious respiratory symptoms seen in COVID-19 patients. Lamellar is focused on treating complex lung disorders and we believe that our Lamellasome formulations could make an important difference to patients and healthcare providers globally."
Profits taken but good luck guys ,could well go up further but in at 0.19,out 0.6 so decent return
Join UP the dots!!! Gla ;-)
Lamellar's Director appointed to the BoD of Motif, confirmed today....RTO into Lamellar looks like a dead cert imho....and Iclaprim, already cleared Phase 11 patient trials, and held up by the FDA at end of Phase 111 patient trials because of toxicity concerns from the intravenously administered drug, they wanted another Phase 111 trial that Motif couldn't afford, and now looks like Lamellar's nebulised inhaler technology's lead compound for the treatment of lung damage in Covid-19 patients could be Iclaprim, which can go straight into patient trials, cutting costs and time and saving Lamellar £10's of millions in its development. Gla holders Fill Ya Boots!!!:-)
1/5/19
Motif Bio Signs Agreement with Lamellar Biomedical
Evaluation of Iclaprim in Combination with LMS-611 for Cystic Fibrosis Lung Infections
Motif Bio plc (AIM/Nasdaq: MTFB), a clinical-stage biopharmaceutical company specialising in developing novel antibiotics, today announced that the Company has signed an agreement with Lamellar Biomedical Limited (Lamellar) under which Motif Bio will conduct an in vivo pre-clinical study evaluating iclaprim in combination with Lamellar's patented LAMELLASOME(TM) technology.
Iclaprim has been granted U.S. orphan drug designation for Staphylococcus aureus pneumonia in patients with Cystic Fibrosis (CF). Lamellar's LAMELLASOME(TM) candidate LMS-611, which has mucokinetic (mucus clearing) properties, has demonstrated antibiotic potentiation (the enhancement of certain properties of antibiotics) and has European orphan drug designation for CF.
The companies believe that, based on pre-clinical data with the two individual components, the combination could be a promising potential treatment for lung infections in patients with CF.
Dr. Graham Lumsden, Chief Executive Officer of Motif Bio, said: "We have been looking for a way to optimise the development of iclaprim in patients with CF. We are excited about the preliminary data we have seen with Lamellar's technology and look forward to evaluating it in combination with iclaprim."
Dr. Alex McLean, Chief Executive Officer of Lamellar Biomedical, said: "CF is a key area of interest for Lamellar. We are delighted to announce this partnership with Motif Bio, which will evaluate the antibiotic potentiation properties of our LAMELLASOME(TM) technology in combination with iclaprim. This collaboration augments our own work in this orphan indication, which is focused on a novel nucleic acid-based therapeutic, as we strive to develop a range of highly effective treatment options for patients with CF."
Appreciate your prompt response with your view on the matter
Yes,but today is a traders dream,and so getting some very nice profits banked.....go with the flow,,,,and know when to run.....and don,t look back....impho
RTO into Lamellar Biomedical Limited, It is so obvious..... No brainer.
Christopher (Chris) Wardhaugh
Chris is currently a Non-Executive Director of Altair Medical Limited and Lamellar Biomedical Limited, both based in Scotland. Chris is also Chief Business Officer of MGB Biopharma Limited, a clinical-stage antibiotic company and is the founder of Sercader Limited, a life sciences advisory firm.
New to this share - so looking for some views on the situation. What are the odds that this company will do a deal before July 28? Because today's news doesn't say anything right
TruthCaller u are corrrect 100%, enough said, once in a life time to get funds back from previous setbacks...GLA
Still looks incredibly unlikely that they'll get a deal over the line in the next 1-2 months... in which case this delists as basically worthless.
Deramping the share price today at this level with today’s RNS(which obviously is a significant shift) is a pure idiocy...
Speculative and very high ..yes ,but to say sell and get out now is wrong..Just..imo,
still holding large chunks and today seems better than many many month before..
Lumsden is no longer the ceo is a relief and ++++
Lamellar is now deeply involved is another +
As always dyor
GL
Mazik....exactly similar amount ....with the chris Wardhaugh and Iclaprim connection is a chance in a lifetime here at these prices imho.
gl
Truthcaller...:-) same here they are not getting mine it took me an hour to get my 750k shares...last year lost lot with motif when they were in discussion for phase 3 Approval, we were buying around 8p, what has changed today replaced the Useless BOD.
No speeding ticket here, as rise due to news!
Probably bought in to negotiate a take over bid ,they have huge tax losses which will be worth a lot along with money spent to get to phase 2.
mazik ...agree ...they aint getting mine. gl
Let me sell can't even buy 100,000 nt
Keeping mine ...its gold dust until it reaches double figures
Not good
Depth 12
11:14 500,000 0.48
11:50 500,000 0.45
11:41 500,000 0.4
11:49 840,000 0.38
10:45 2,300,000 0.315
10:41 500,000 0.301
09:50 555,000 0.27
11:33 500,000 0.25
11:45 500,000 0.25
09:19 25,000 0.23
07:50 3,000,000 0.16
07:52 1,500,000 0.15
13 Depth
0.5 50,000 11:49
0.55 350,000 11:48
0.599 662,939 11:49
0.62 49,000 11:38
0.65 500,000 11:50
how is L2 looking?