Total Voting Rights - Replacement

International Biotechnology Trust plc (the "Company")

The following amendments have been made to the 'Total Voting Rights' announcement released on 28 February 2020 at 17:18 under RNS No 5778E.

The total number of shares held in Treasury has been amended from 2,903,176 to 2,916,476.

The total voting rights in the Company has been amended from 38,439,487 to 38,426,187.

All other details remain unchanged.

The full amended text is shown below.

Voting Rights and Capital

In accordance with the FCA's Disclosure Guidance and Transparency Rule 5.6.1R the Company would like to notify the market of the following:

At the close of business on the 28 February 2020, the Company had 41,342,663 Ordinary shares in issue, of which 2,916,476 were held in Treasury. Therefore the total number of voting rights in the Company was 38,426,187.

The above figure (38,426,187) may be used by Shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure Guidance and Transparency Rules.

Susan Gledhill

For and on behalf of

BNP Paribas Secretarial Services Limited

Company Secretary

Telephone: 020 7410 5971

2 MARCH 2020