Publication of Final Terms

NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION

Publication of Final Terms in relation to the issue of €2,200,000,000 fixed rate euro medium term notes

AstraZeneca PLC has published the following Final Terms:

Final Terms dated 11 May 2016 (the "Final Terms") relating to the issue by AstraZeneca PLC of €2,200,000,000 fixed rate euro medium term notes (the "Notes") pursuant to its U.S.$5,000,000,000 Euro Medium Term Note Programme (the "EMTN Programme") comprising:

· €500,000,000 of 5-year fixed rate notes with a coupon of 0.25%

· €900,000,000 of 8-year fixed rate notes with a coupon of 0.75%

· €800,000,000 of 12-year fixed rate notes with a coupon of 1.25%.

The Final Terms must be read in conjunction with the base prospectus for the EMTN Programme dated 5 May 2016 (the "Base Prospectus").

The proceeds of the issue of the Notes will be used for general corporate purposes, which may include repayment of debt.

To view the Final Terms for the above mentioned issues, please paste the relevant URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/9359X_-2016-5-11.pdf 

http://www.rns-pdf.londonstockexchange.com/rns/9359X_1-2016-5-11.pdfhttp://www.rns-pdf.londonstockexchange.com/rns/9359X_2-2016-5-11.pdfA copy of the Final Terms for the above mentioned issues will shortly be submitted to the National Storage Mechanism and will be available for inspection at:

http://www.morningstar.co.uk/uk/NSM

Disclaimer - intended addressees

Please note that the information contained in the Final Terms (when read together with the information in the Base Prospectus) may be addressed to and/or targeted at persons who are residents of particular countries (specified in the Base Prospectus) only and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Final Terms and the Base Prospectus is not addressed. Prior to relying on the information contained in the Final Terms and the Base Prospectus you must ascertain whether or not you are part of the intended addressees of the information contained therein.

In particular, the Final Terms and the Base Prospectus in respect of the Notes do not constitute an offer of securities for sale in the United States. The Notes have not been, and will not be, registered under the U.S. Securities Act of 1933, as amended, (the "Securities Act") or under any relevant securities laws of any state of the United States and may not be offered or sold to, or for the account or benefit of U.S. persons or persons within the United States of America, as such terms are defined in Regulation S under the Securities Act, except in certain transactions exempt from, or not subject to, the registration requirements of the Securities Act. There will be no public offering of the securities in the United States.

Your right to access the Final Terms is conditional upon complying with the above requirement.

A C N Kemp

Company Secretary

11 May 2016