Posting of Circular & Annual Report & Notice of GM

Itaconix PLC

 ("Itaconix", "the Group" or "the Company")

Posting of Circular and Notice of General Meeting

& Posting of Annual Report and Notice of AGM

Further to the Company's announcement of 12 July 2018 that it has conditionally raised £3.4 million before fees and expenses by a Placing with certain existing and new institutional and other investors and by a Subscription with certain existing US eligible shareholders and up to a further £1.0 million via an Open Offer and US Additional Subscription, Itaconix confirms that the Circular (containing a notice convening the General Meeting) has been posted to Shareholders and will shortly be available for download on the Company's website: www.itaconix.com.

The General Meeting has been convened for 2 August 2018 at 11.00 a.m. (B.S.T.) at the offices of Fieldfisher, 9th Floor, Riverbank House, 2 Swan Lane, London EC4R 3TT, United Kingdom.

The Company also announces that its Annual Report and Accounts for the year ended 31 December 2017, including its Notice of Annual General Meeting ("AGM"), has been posted to shareholders and Companies House and will shortly be available for download on the Company's website: www.itaconix.com.

The AGM will be held on 9 August 2018 at 11.00 a.m. (B.S.T.) at the offices of Fieldfisher, 9th Floor, Riverbank House, 2 Swan Lane, London EC4R 3TT, United Kingdom.

For further information, please contact:

Capitalised terms used in this announcement shall, unless defined in this announcement or unless the context provides otherwise, bear the same meaning ascribed to such terms in the announcement made by the Company on 12 July 2018 to announce the launch of the Fundraising.