Notice of AGM

NOTICE OF ANNUAL GENERAL MEETING

AstraZeneca PLC (the Company) announced today the publication of its Notice of Annual General Meeting 2016 and Shareholders' Circular, together with a covering letter from the Chairman.

Copies of the documents have been submitted to the National Storage Mechanism and will shortly be available for inspection at www.morningstar.co.uk/uk/nsm. The documents are also available on the Company's website at www.astrazeneca.com/agm.

The Company's Annual Report and Form 20-F Information 2015 and AstraZeneca 2015 In Brief were published on 8 March 2016.

The above documents are being despatched to shareholders today.

The meeting place for the Annual General Meeting (AGM) will be the Lancaster London Hotel, Lancaster Terrace, London, W2 2TY and the AGM will commence at 2.30 pm (BST) on 29 April 2016.

Since the effective date of the Company's Annual Report and Form 20-F Information 2015, it has been announced that Leif Johansson, Non-Executive Chairman of AstraZeneca PLC, has declined re-election to the board of Svenska Cellulosa Aktiebolaget SCA (publ) at SCA's annual general meeting, which will be held on 14 April 2016.

A C N Kemp

Company Secretary

18 March 2016