Holding(s) in Company

20 Feb 2008 14:26

Proteome Sciences PLC ("the Company") Notifiable Interest

A form TR-1 containing the following information has been received by the Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

5. Date of the transaction (and date on which the threshold is crossed or reached if different):

19th February 2008

6. Date on which issuer notified:

20th February 2008

7. Threshold(s) that is/are crossed or reached:

28. Notified details:Below 3%

A: Voting rights attached to shares

Class/type Situation previous to Resulting situation after the of shares Triggering transaction triggering transaction

if possible Notification required under DTR using ISIN transitional provision 7

CODE Number of Number of Number Number of % of voting Shares Voting Rights of voting rights rights shares Direct Direct Indirect Direct Indirect

GB0003104196 4,016,641 4,016,641 Below Below Below

3% 3% 3% B: Financial Instruments

Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that may % of financial date Conversion be acquired if the instrument is voting instrument Period/ Date exercised/ converted rights Total (A+B)

Number of voting rights % of voting rights

3,910,513 Below 3%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

10. Name of the Proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:14. Contact name:15. Contact email address:Tr1@mfglobal.com