Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 31 December 2015, Cori Bargmann, a Director of the Company notified us that, on 30 December 2015, she became interested in 2,500 AstraZeneca PLC American Depositary Shares (ADSs) at a price of $34.42 per ADS as a result of a purchase of shares on the New York Stock Exchange.

Two ADSs equal one AstraZeneca PLC Ordinary Share of $0.25.

A C N Kemp

Company Secretary

4 January 2016