Director/PDMR Shareholding

Transaction by Person Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

On 3 January 2016, Pascal Soriot, a Director of the Company, notified us that, on 31 December 2015, he ceased to be beneficially interested in 250,100 AstraZeneca PLC Ordinary Shares of $0.25 each as a result of a gift of those shares to family members for nil consideration.

A C N Kemp

Company Secretary

4 January 2016