Ixico Regulatory News (IXI)

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Phytopharm plc

2. Reason for the notification  (please tick the appropriate box or boxes)

An acquisition or disposal of voting rights

X

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify): Placing and a change in the ISC

3. Full name of person(s) subject to the notification obligation:

Henderson Global Investors

4. Full name of shareholder(s) (if different from 3.):

5. Date of the transaction (and date on which the threshold is crossed or reached if different)

24 September 2012

6. Date on which issuer notified:

25 September 2012

7. Threshold(s) that is/are crossed or reached:

12%

8. Notified details:

A: Voting rights attached to shares

Class/type of shares

 if possible using the ISIN CODE

Situation previous to the Triggering transaction

Resulting situation after the triggering transaction

Number of Voting Rights

Number of shares

Number of voting rights

% of voting rights

Direct x

Indirect xi

Direct

Indirect

Ordinary 1 Pence

GB0006869720

38,247,242

38,247,242

41,697,242

12.02%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ Conversion Period/ Date

Number of voting rights that may be acquired if the instrument is exercised/ converted.

% of voting rights

Total (A+B)

Number of voting rights

% of voting rights

41,697,242

12.02%

9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

Notification using the total voting rights figure of 346,801,972

14. Contact name:

Zoe McGowan, Company Secretary

15. Contact telephone number:

01480 437697