BTG Regulatory News (BTG)

TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi

1. Identity of the issuer or the underlying issuerof existing shares to which voting rights areattached: ii

BTG plc

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

ü

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

3. Full name of person(s) subject to thenotification obligation:

Novo Nordisk Foundation

4. Full name of shareholder(s) (if different from 3.):

Novo A/S

5. Date of the transaction and date onwhich the threshold is crossed orreached:

18 December 2015

6. Date on which issuer notified:

21 December 2015

7. Threshold(s) that is/are crossed orreached:

4%

8. Notified details:

A: Voting rights attached to shares

Class/type ofshares

if possible usingthe ISIN CODE

Situation previousto the triggeringtransaction

Resulting situation after the triggering transaction

NumberofShares

NumberofVotingRights

Numberof shares

Number of votingrights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

Ordinary 10 pence shares

ISIN:

GB0001001592

15,110,625

3.95%

15,330,065

15,330,065

-

4.00%

-

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financialinstrument

Expirationdate

Exercise/Conversion Period

Number of votingrights that may beacquired if theinstrument isexercised/ converted.

% of votingrights

N/A

-

-

-

-

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments xv, xvi

Resulting situation after the triggering transaction

Type of financialinstrument

Exercise price

Expiration date

Exercise/Conversion period

Number of voting rights instrument refers to

% of voting rights

N/A

-

-

-

-

Nominal

Delta

-

-

Total (A+B+C)

Number of voting rights

Percentage of voting rights

15,330,065

4.00%

9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi

The qualifying instruments are held by Novo A/S, the holding company in the Novo Group. Novo A/S is wholly owned by the Novo Nordisk Foundation.

Proxy Voting:

10. Name of the proxy holder:

-

11. Number of voting rights proxy holder will ceaseto hold:

-

12. Date on which proxy holder will cease to holdvoting rights:

-

13. Additional information:

-

14. Contact name:

Andy Burrows, Vice President, Corporate and Investor Relations, BTG plc

15. Contact telephone number:

020 7575 1741