Roundtable Discussion; The Future of Mineral Sands. Watch the video here.
Bit bored of consolidation. Doesnt bother me either way. Im looking for the tox data.
Is it detailed enough to compare with other approvedin trial drugs and avoid black box warnings or dose limits.
1. Best case yes. Mega blockbuster $12 bn plus drug (otezla on speed)
2. My expectation. A bit mixed. But there is space for 4 or 5 tyk2s in the market each with its own indications profile. Still a 2bn plus drug.
3. A dunce on safety. Possible but unlikely.
Will we get data to compare against other drugs ? Its what im looking for. And if we do get it probs needs expert review well above my payscale to understand the implications. So im waiting for tox data. Then for experts to interpret what it means.
1. Molecule designs done. Patents filed and mostly granted.
2. Now into trials. Credibility in organising those ? Not for 20 years.
3. Utterly dilatory in not getting tox data out. A 100m cap player is quite different from a microcap punt.
4. May be time for TM to step aside and become an advisor. And put someome in who can release results in a timely manner. Amateur hobby time is over. Step up. Or stand aside with some dignity.
https://vm.tiktok.com/ZML2VtADT/
Too true. Bit off topic. I was given 2 years a year ago. Fuuuuck. C19 had royally screwed me. Finally went to the quack as i broke my ankle having avoided hospitals as thats where most people die. Vitamin deficiencies. Laid off the booze. Quite sobering literally. Dont put off seeing the quacks. No point making ****loads if your dead before you spend it. Much love and dont squabble. Life can be too short sometimes xxxx
Consolidation costs sweet fa. Swag estimate 250 k all in. Bigger costs are if going for a new listing. Swag again 200k pa. Plus upgrading auditors etc. Personally dont give a ****. If it gets us to a 5× valuation. Vc funding. Money well spent. See altium (aka esker) ive referenced before. Gates has a new book out on preventing pandemics in future. Probs worth a tenner. Front of mind. And the best news im not dead in the immediate future apparently. So have to find all the paperwork i gave to my wife to remove the incentive to cook for me again.
Dp. Still here. Some health issues so the sooner i retire to the sunsine the better. Not doing internet so much apart from watching shuffledances on tik tok which makes me feel younger strangely :). Num4 spot on as usual. Silence used to be sr pharma. 2 boffins messrs stanford and rook.with a patent on a bacterium. Microcap at the time. And look at it now. Makes me feel old again as it must be 25 years i made a few bob on it.
Hbd. Worth a read.
https://www.mckinsey.com/industries/life-sciences/our-insights/the-uk-biotech-sector-the-path-to-global-leadership
My benchmark is esker therapeutics. Tyk2 start up without a patent. Achieving a $1bn valuation in the states. That is where i hope we are heading.
Woken up from the blue fog.
Ideally a precursor to a nasduq listing. Should see a 3 to 5 times multiple in sp based on lesser companies in our space (see esker therapeutics aka altium). Better valuations over the pond. Bring it on. Now where is my camberwell carrot. Nursey says its sleepytime again. If its a road to USA profile sp will multiply based on comparable cos. Gla
Rnm better at the maths than me. But i have $40 bn sales notched in my head.
Lung cancer $16bn
Anogential $16bn
Pancreatic $6bn
Ovarian $6bn
All without good options currently. Just need one combo to stick a bit. Gla. 1bn a year royalties feasible but a fraction and we are still minted.
Xviolet. This is the one peeps need to **** themselves about.
https://www.livemint.com/science/health/wuhan-scientists-warn-of-deadlier-variant-of-coronavirus-read-here-11643363918168.html
crossover with MERS. 30% fatality rate. No immunity. Pray to your gods it doesnt cross over. And I will repeat stay away from camels as they host both viruses where they can recombine.
Esker Therapeutics (now renamed Alumis). Basically a Tyk2 startup. unpatented molecule. Have raised c $270 from 2 VC funds for c 18% of the shares via series A & B rounds. Would put them well over $1Bn valuation.
https://www.crunchbase.com/funding_round/esker-therapeutics-series-b--a6ec1e2a
so its just a patient arbitrage for me. Getting more USA investors good as vlauations more favourable. we are much further ahead with better patents. just patience as ever as arbitrage does its thing and we should be 5 times higher already. GLA
I think C19 ratcheted back up the list. as expected.
I warned over a year ago that the doomsday scenario is C19 merging with MERS or SARS (which have c30% mortality rates), and belong to the same coronovirus family (hence my flippant comments about not ****ing camels.)
Its arrived. Whether it will proliferate to be seen (Im actually bored of C19 SOO much). but keep this on the radar. If it does proliferate the powers that be that write the checks will start ****TING themselves as it really is a domesday scenario. 30% population wipeout.
https://www.jpost.com/health-and-wellness/coronavirus/article-694885
keep an eye on it.
Getting the warrants out of the way before Tox results.
Tox Results within 10 days
Introducers duly incentivised to do more introducing.
Not beholden to brokers anymore we have been underserved by.
New investors and introducers seem to be US based (can only be a good thing going international).
Yes its a schoolboy error, and there have been a few.
But in the scheme of things all moving in the right direction for me. But Im here until the endgame.
Whilst are off piste.
An accountant,lawyer and an actuary are having a beer debating whether its better to have a wife or a girlfriend.
Accountant- wives are better as you can spread tax allowances on your profits.
Lawyer- girlfriends are better as you dont lose your house.
Actuary- its better to have both. When you phone up to say you will be very late. Your wife thinks you are seeing your girlfriend. Your girlfriend thinks you are staying in with your wife. Which gives me the perfect excuse to get in some extra hours at the office.