Member Info for maidit308

there is a reason SAR Tweet BMS readout 3 days ago''
perhaps they are trying to tell us that our TYK2 1801
is still the only none tox left in the room asT2 would say..
no headache LOL!!

While BMS waits for TYK2 inhibitor's psoriasis nod, a new path potentially clears in lupus

Over two years, an overall safety profile consistent with that seen in the shorter trials was observed. Adverse events continued to be predominantly mild or moderate, with the most common events still being nasal inflammation, upper respiratory tract infection..

depend on what they are calling mild or moderate, LOL!!

come on SAR'' you know you are still the best in class
and us investors of the dream for many years, have always known..

''when your ready''

GLA

many thanks for posting that GSK announcement link BOB''
that's the link i was hoping someone post yesterday for DX'' who ask for information
on the 737 related, the line of interest is this text'' we all should take note off
baring in mind that SRA515 is the COMBO for SRA737 bought from AZN...

In addition to momelotinib, the pipeline consists of two assets in phase I SRA515 and SRA737. SRA515 is a selective bromodomain-containing protein 4 (BRD4) bromodomain and extra-terminal domain (BET) inhibitor with a novel bivalent binding mode that inhibits both protein bromodomains, and SRA737 is a novel checkpoint kinase 1 (CHK1) inhibitor.

they mention SRA515 is a P1 but no mention that SRA737 is a P2 solid tumor??
and the real target'' IMO..

hiding this good thing away is futile IMO, and it will all come out in the wash
at some point, when more detail on this huge deal come to light

patient, hold on to your golden ticket,

308..

LOL!! HERB'' it sounds like you are out M8 and very bitter ATM
looking to pick a fight, with any positive post

ZAK take on this suspension...

It will be interesting to see whether the naysayers finally get their comeuppance and the bulls their big M&A deal?

i have always had a feeling myself that before any big SP moving M&A or otherwise
announcement, we would get suspended, and come back double the price or treble the price..
depending on what it is.. I WOULD HATE TO BE OUT RIGHT NOW''

we will see in the hours ahead / days ahead / months ahead
as we have no control as to when they will tell us..

308..

now where have we seen this before???
big news coming IMO, pending a big announcement NN buying the lot
or the Chinese?

we will see

what a horrid thought BIKER''

HI DX' a bit more on the related SRA737 to GSK Sierra buy
as no one has post that link'' this is the gist of it... tweeted by SAR..

On 13 April, GSK announced its intention to acquire Sierra Oncology for $1.9bn (a 39% premium to the closing price on 12 April). The deal is part of GSK’s efforts to bolster its oncology franchise as it looks to move away from its consumer health business. Sierra’s lead asset, momelotinib (targeting myelofibrosis, a haematological cancer of the bone marrow), has recently completed Phase III studies, with plans for US and EU regulatory submissions before end 2022. We note that in late 2021, Sierra had indicated revived interest in developing SRA737 as a potential combination therapy (both haematological malignancies and solid tumours) following its in-licensing of the BET inhibitor AZD5153 (now known as SRA515) from AstraZeneca (August 2021). According to the latest available information, Sierra was in the process of finalising trial designs for the three possible studies assessing SRA737 as a combination treatment.

While we await more information from the companies involved on their future plans for the pipeline assets, we believe that GSK will also explore the possibility of continuing to develop Sierra’s remaining pipeline given that momelotinib is ready to transition to the market and the fact that Sierra’s developmental pipeline aligns with GSK’s oncology/haematology focus. If GSK decides to retain the pipeline, we expect development work on SRA737 to accelerate given the greater financial resources at hand. This should work in Sareum’s favour as it holds a 27.5% economic interest in SRA737. The favourable response of Sareum’s share price following the announcement suggests renewed optimism in the market on SRA737’s prospects, pending further details from the companies involved.

regards..

Licence agreement for CCT245737 now known as SRA737

27th Sept 2016 6 years ago and counting and now sold to GSK in a package

potential future milestone payments of up to US$88.4 million, some of which are expected to be paid within the next twelve months upon certain development milestones being met

P2 been met and completed is a huge milestone, IMO and we should have
gotten some of that $88m a long time ago, that's my contention..
and although it's in good hands with deep pocket to get 737 to P3
there is still a question mark lingering... that we was mugged off from the start
but will still have the last laugh with 1801 / 1802 100% own, going in the clinic shortly
+ we are in the pounds

good post Seawolf'' as we only find out that P2 has been completed
from TM last presentation slides, SIERRA did not say anything in that regards
because they would have to pay that long awaited milestone of only £500k
+ the limelight that would have come with it, LOL!! greedy BSDS

yes that $1.9b deal with GSK should be investigated IMO,
because SRA737 p2 for solid tumor, that they are getting as a package
would be worth a lot more money than $1.9b on it's own..

best Regards..

DES'' GSK is buying Sierra, and sierra has a p3 compound + SRA 515 /SRA 737 P2
although they did not say'' in that GSK statement of buy out
there was only a quick mention in one of TM presentation that P2 completed for solid tumor
that got us talking on this BB a few weeks back as we all though SRA737 was a P1/2 compound
Sierra left on the shelf

the link to that GSK $1.9b buy out of Sierra, was posted on this BB
i month ago, go back and find it yourself and see what was said, or if someone
on here could kindly post it again, or go on Sareum website / twitter it's on there..
from what i have seen of it, only 3 compound was mention and 737
was one of them, figure it out yourself

the p3 compound that GSK is buying Sierra to get, is a $1.5b a year Market
and SRA 737 P2 solid tumor is a $400bil a year Market
i know what one i would be interested in'' if i was GSK''

DES'' just related speculation with reason, going by what i have seen so far
and research, as your post seems a bit vague M8

anyway hope it helps

Regards

the Ukrainian Army has had there biggest fight back,
since the Special operation started, and are pushing the invaders
further and further from most territory Hmmmmm GB News Just now''

and back to Russia hopefully?? to rethink there position
and standing in the world before it's too late,

anyway everyone should tune in to Mark right now he is talking about
3 shots of the VAX kills and you are more likely to pass it on
and no one in any government want to have a grown up conversation
around his findings from around the world very interesting

afternoon all, well we did not get that expected update, after so many sign
that 1 is on it's way over the past 2 weeks, since BIO presentation

some say a TR1 is expected with the amount of big buy trade we have seen lately..
they could be right, as there is only 68m in issue, they have to tell us at some point
''HNWI snapping up some more on the open market, who knows??

anyway'' we are another week closer to the clinic with a blue finish
on slippery Friday LOL!! and plenty to be excited about, now that GSK
has shown there hands 737 related, and is looking at what else
SAR has in the shop window under the quiet, some would say''

looking forward to the week ahead already...

308

well we never got that expected RNS this week, get over it''

there is plenty of time for those that slate of other posters for keeping
up good sentiment on here, to take profit on any news that comes or don't come next week..
don't feel so hard done by'' cause one did not turn up this week..

no one know when news will come we can only speculate that 1 is coming
going by the huge volume of buys over the past 2 weeks,
and i don't think we have to worry about the GB PGM sanction,
as that will only push the price up a lot higher, Boris got it wrong again
perhaps got a short going LOL!! and will soon backtrack as he does
when big CO start moaning about the 35% extra they have to pay
£1..4 bill of sanction, is hardly going to hurt Russia, another silly decision IMO

anyway'' breaking news on sky just now, about Putin health
and that the war will be over August?? Ukrainian are fighting hard
and plan to push them out of all territory, the story is certainly getting around''
CAW''

something is happening give it time, and as said by a few on here INC myself
we will bounce around the 8 to 9 / 10 until the BOD tell us something
good or bad

good weekend

everyone talk about the SP in the stock they are invested in
you wouldn't be human if you never,

most off the chat on LSE / AIM / SAR thread is about movement / boooom / trade /showing up 20% /
spread / buys / sells / all SP related'''

you show me a stock on AIM that no one talk about the SP??

the only person on here that don't talk about the SP much is C79
he mostly post link to the science, and nothing else WELL DONE C79
RMM T2 A3 and a few more, keep up the good work, without you guys
on here sometime, we would have nothing to talk about..

anyway i got a lot of money invested here, been around SAR from 2010
look at my posting history, double my holding on the drop to £1,
and i think i post at the time, that it was too good an OPP to miss, as we are worth at least £3
we went to 3.40p 1 month later, and 1 of my last post i said 2.20p is looking like the new base
and we are trying to move away from that now''

and the last time i look it's a free BB to chat SHT
or slate of other posters it's more popular you get lots of thumbs up
if you do that LOL!!

good weekend

https://www.fiercebiotech.com/biotech/bms-new-safety-data-psoriasis-drug-puts-company-track-third-new-drug-launch-2022

lovely blue close to the week, as expected, and an excellent Friday ...

same again next week hopefully

the tide is turning

good weekend

308..

manipulation,'' none stop buying for the last 3 hours, as far as i can see
and with the troops been chase out of every town ATM, the last i have heard,
and with 9m buys to 3m sells SP can only go 1 way

up up up up up LOL

happy Friday all

Regards

308..

we are going to see a good move today''

and hopefully a red dot to give us the best Friday ever..

GLA

some nice buying action this morning and although we are down
a little bit, i would not be surprise to see blue shortly

as i think the Market knows that a red dot is due anytime from now''
any sells will be snapped up under 8p it's always up to MM
when they let it go, they will mess us about for awhile, under 8 over 8 but SP
will only go 1 way when its ready

ATB

308..

you needing financial advise,for that type of money as an answer, from W 1986''
is as good as you are going to get billy big BOLX LOL!!
as you won't get it here, all we can say is research research and research
some more and make your own mind up

we are doing quite well since the drop to £1 IMO,
and holding the 220p base level quite strongly as if it's getting ready for a run..

and yet another 1 for the believers today, that's 5 so far this week??

will we get something on slippery Friday??

time will tell

GLA