Member Info for Laura2022

"Our findings validate P140"

be an effective strategy to reduce tumor survival, we have used the phosphopeptide P140, known

to restore aberrant CMA upregulation in specific immune cells. We found that administration of P140

peptide in an immunocompetent GB mouse model with both patient-derived GSCs and GB cell lines,

neutralizes GB-induced PC CMA upregulation resulting in ablation of PC-tumor cell interactions and

triggering of a secretome toxic to tumor cells. We identified MAPT/tau, a known CMA substrate, as one of

the main components of this secretome, and discovered that CMA-dependent PC MAPT/tau secretion

within the GB TME plays a key role in cancer progression and recurrence. Furthermore, we found that

perivascular accumulation of MAPT/tau is an effective way to monitor peptide P140 treatment efficacy in

GB and for prognosis of the patient evolution. Our findings validate P140 peptide treatment as a safe and

specific strategy to halt GB progression and establish the clinical relevance of extracellular MAPT/tau as

a biomarker for therapeutic success

Many thanks Eric

"Malani argued that more efficient procurement and industrial strategy could deliver major savings"

This is what RCFX offer

Housebuilder Vistry has launched a voluntary redundancy programme as it moves to cut costs and preserve cash, The Sunday Times reported. The company, formerly a FTSE 100 constituent and often described as "Labour's favourite housebuilder", is understood to have written to all staff below managing‑director level offering voluntary exit terms. In a memo to its 4,500 employees, chief executive Adam Daniels said the scheme formed part of the "next phase of our journey" and was aimed at staff who felt "less connected" to the group's direction or uncertain about their future.

From Sunday paper round up on LSE news feed

Britain could save billions of pounds on defence spending if it adopted the procurement approach used in the US and Germany, according to The Times, citing comments from Shonnel Malani, European co‑head of Advent. Malani said the UK needed to "mobilise the full strength of Britain" following the shock resignation of defence secretary John Healey over planned cuts to armed forces budgets. Advent has invested around $15bn in defence since 2020, including the £4bn takeover of Cobham and the £2.6bn acquisition of Ultra Electronics. Malani argued that more efficient procurement and industrial strategy could deliver major savings.

TCG

From the very onset it was clear many on here had obvious agendas and jekll and hyde

Filter button is the best medicine

Thanks Cav

The investment, which will be spread over the next four years, would allow the MoD to fund all 62 recommendations in the Strategic Defence Review. This includes its programme of capability investment, spanning autonomous systems, nuclear deterrence, land forces modernisation, and digital transformation.

Current defence spending stands at 2.4% of GDP ahead of the commitment to reach 2.5% by 2027, with Starmer pledging to raise investment further to 3.5% in the future.

Against this backdrop, #RCFX is helping to support the Ministry of Defence strengthen the UK's sovereign capabilities, in an increasingly volatile geopolitical landscape. Visit our website to learn more:

Could you copy it please as lnk wont open

Wigw

Well said, it why i filtered many years ago

He never actually seemed to buy ANYTHING, jist ponticated and trolled other shares

1.72mln and voted NO

Ditto re: Eric p140 research

Imho

Printed 6 times but corrected twice , so either two 130 grand sells or some form of isa roll trade

Either way it seems to signal something in the offing

Looks like interesting week next week

3p paid

Why has it fallen SO much given there is other interest?

Tia

That Glass Lewis report Rns was pitiful

They KNOW they have misjudged this

Thanks JVIP

Cash levels 7p+ so long way yet

Best wishes

Thanks kindly

Many people are just odd ;)

Check 2mth chart

Crazy oversold