RNS today31 Mar 2026 07:04
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31 March 2026
Solvonis Therapeutics plc
("Solvonis" or the "Company")
Granted U.S. Patent from PTSD Discovery Programme
Solvonis Therapeutics plc (LSE: SVNS), an emerging biopharmaceutical company developing novel small-molecule therapeutics for high-burden central nervous system ("CNS") disorders, announces it has been granted a U.S. patent by the United States Patent and Trademark Office ("USPTO") covering a monoamine modulator compound series arising from its proprietary post-traumatic stress disorder ("PTSD") discovery programme.
The patent, U.S. Patent No. 12,590,077, covers a monoamine modulator compound series designed to modulate serotonin, dopamine and noradrenaline transporter systems (SERT, DAT and NET).
PTSD is a large and underserved market affecting more than 20 million people across the UK, U.S. and major European markets, with limited approved pharmacological treatment options. Recent strategic activity in the sector, including Otsuka Pharmaceutical Co., Ltd.'s ("Otsuka") agreement to acquire Transcend Therapeutics for total potential consideration of US$1.225 billion, highlights growing strategic and commercial interest in next-generation PTSD treatments.
As a composition-of-matter patent, it protects the underlying compounds themselves rather than only how they are used or manufactured. This is generally regarded as the strongest and most commercially valuable form of patent protection in drug development.
The granted patent builds on the Company's previously announced USPTO patent allowance in January 2026 in relation to compounds arising from its PTSD discovery programme. Since that milestone, Solvonis has also selected SVN-114 as the lead candidate from the programme.
Importantly, this patent is part of a broader protected chemistry estate being built around the Company's PTSD discovery programme, providing additional optionality for future optimisation, lifecycle management and potential follow-on development.
Anthony Tennyson, CEO of Solvonis Therapeutics plc, commented: "This patent strengthens the long-term value of our PTSD programme in an area of clear unmet need and rising strategic and commercial interest, highlighted by Otsuka's agreement to acquire Transcend Therapeutics for total potential consideration of US$1.225 billion. Strong intellectual property is central to value creation in biotech, and securing composition-of-matter protection at the level of the underlying compounds materially strengthens our position. Importantly, it supports a broader chemistry platform beyond a single asset, giving us greater f
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