Member Info for CHELSEA7

And a bigger one at 8.025!!!! Night guys, take it it went well.

Well someone has just bought 37k at 8p. Should be winding up now.

And further Ivy, you don"t speak for me, nobody does. You sound as if you are inciting mob culture!!!!!

Nobody here claims to know the BOD, like you do with MTFB, and in fact the more you speak, you sound like a bully, and wait for Bermudashorts to post first, then you do. Very different to the Ivy who started off investing in every failed biotech.

With all due respect..................... .Inanaco if you can’t detect the vitriol especially on ADVFN !!!!

Since when has ADVFN been a marker for anything but vitriol!!!

You seem to be on a very high horse these days, for a share you delight in saying you only have a small holding in, and rather than discuss other childrens anger, perhaps it might be more mature to behave like adults.

Good luck, welcome to the BB 1st Tee

bobbust, I don"t think anyone has questioned that at all/

If your"e going today, and all others have a good un, GL guys.

Morning Ruck, well first thoughts......

1) More potential

2) More money

Scancell Holdings plc, the developer of novel immunotherapies for the treatment of cancer, today announces an update on the development of its second vaccine from its proprietary Moditope platform, Modi-2. Pre-clinical data demonstrates that homocitrullinated peptides induce highly potent T cell responses, tumour rejection and increased survival in murine models.



Moditope represents a completely new class of potent and selective immunotherapy agents based on stress-induced post-translational modifications (siPTMs) which could have a profound effect on the way that cancer immunotherapies are developed. Scancell's lead Moditope vaccine, Modi-1, acts by stimulating the production of CD4 T cells using citrullinated tumour-associated peptide epitopes, which overcome self-tolerance and destroy tumour cells. Modi-2 exploits a new modification, stimulating the production of CD4 T cells using homocitrullinated tumour-associated peptide epitopes. Whereas citrullination involves the conversion of the amino acid arginine to citrulline, the process of homocitrullination involves the conversion of lysine to homocitrulline. Scancell believes this second mechanism of action has the potential to broaden the utilisation of the Moditope platform.



Modi-2 is currently in pre-clinical development and work is underway to characterise specific homocitrullinated peptides for clinical development that have the potential to address different cancer indications to Modi-1, including tumours with a particularly immunosuppressive environment. The Modi-2 peptide family is the subject of new intellectual property applications with a view to extend the Company's dominant patent position in relation to post-translational modifications of cellular proteins and their application in the treatment of cancer.



Prof Lindy Durrant, Chief Scientific Officer of Scancell, commented: "We are pleased to be able to provide an update on the progress of our second Moditope vaccine, Modi-2. The data clearly demonstrates the potential of homocitrullinated, as well as citrullinated, tumour-associated peptide epitopes to be developed for the treatment of solid cancers."



Prof. Durrant will provide an overview of Modi-2 and its potential as a new vaccine for the treatment of cancer at the Company's AGM today. Her presentation will be available on the company website, www.scancell.co.uk.

https://www.investegate.co.uk/scancell-hlds--sclp-/rns/identification-of-2nd-moditope-cancer-vaccine/201810300700085965F/

Hanoi, will be very surprised if we haven"t got an RNS this morning, out at 7 if you"re around.

Morning Hanoi, yeah I saw it, haven"t really been posting for a bit, but my MRI scan is now tomorrow, call it the wonders of NHS communication, lol. Thanks for remembering buddy.

There was nearly a million trades Friday too, mostly buys, time to see the delayed sells, me thinks.

Trust the guys will find out a few important things, I have so many questions can"t see much point posting until the most important we have answers too.

Take care buddy, fingers (and toes) crossed!!!......and for tomorrow big time ATB

Expected a few on Friday, when a million shares were traded, less than 10% sells, and yesterday 650k traded, virtually all buys, with the SP stuck on 7.75.

Looking out for them tomorrow, must be up to a 1m to come.

Only read a few posts here since last week, but more important than the losses we have (nearly all) incurred, the anger screams out. Just hoping tomorrow doesn"t reflect in any way the goings on in 2015, something that has slightly irritated me is all these issues were brought up by me many months ago, when the first deadline for the SCIB1 trial was passed.
I don"t think one poster spoke of my concerns, went through the inanaco/TF book of insults as a result and here we are now.

There are so many issues i would like answers on, the year is nearly over the concentration with all due respect should be on 2019.

I understand the anger of many, but would hope that is curtailed until after the AGM, when Q & A are invited from the floor. The BOD must know the atmosphere around, so i will go for an RNS in the morning, and many concerns dealt with during their presentation, leaving us to focus on the important issues not addressed. Very sorry i cannot attend, there are many questions i need answering. and frankly couldn"t even buy at 7.75 yesterday as i"d rather hear their plans first and make my mind up accordingly, if it even i hope means paying more.

Thanks to those who can attend, trust we are in good hands, and my only fear is a repeat of 2015. There will be losers........us!!!!

So have a good meeting and look forward to hearing your comments after, and again thanks for going.

Morning Filbert, always in my mind on AGM Day, never more so today. Slept through the weekend and was saddened to hear of the helicopter crash Saturday evening. that claimed the lives of so many at Kingsmeadow on Saturday. My thoughts to you buddy, and all involved with L.F.C.. sending my very best P.

Good luck guys, have a fruitful day.

Not sure how you guys have got into such a long debate, in any case we might just get an RNS Tuesday morning which will lighten up the general mood amongst us totally. I tend to find a tone in some of Ivys posts which make me unsure of what he is aying, but I think his post as early as 09.22 was very clear and explained much of what has been said since. So I will repost it for those who havent seen it, or for those that have and have forgotten it..........................

I am sure that the tone of e mails received in the last few weeks by SCLP will ensure discreet security and the BOD will expect some tough questions so yes may be lively.
However it is the reaction of the BoD that will imo determine how lively it is.
I think they would be well served by taking some heat out of the situation by giving their normal presentation with a fuller update and explanation of delays without of course giving out anything material.
Then by at least answering the audience questions openly and directly and also make themselves available afterwards which they normally do and certainly did last year.
If they make the mistake again imo of retreating into their shell and putting up barriers and refusing to answer genuine questions or hiding behind protocols and/or bad body language as they did to a large extent in 2015 then I fear the reaction will not be good.
There will be a lot of frustration in the room giving the recent SP action but equally the many PIs who attend are very reasonable people who wil give the BOD an opportunity to show humility or be contrite.
It is purely if the BOD say none of it is their fault and the Investors simply accept the risk of investing whilst at the same time refuse to acknowledge their increased compensation is somehow disconnected from the SP performance which the vast majority of SH have endured.ie they must show sone form of alignment.
For the record I am expecting a decent meeting and a very good opportunity to get a much better feel for the future but am fully cognissant of the background to the meeting."""

Well i was pleased to read that, I wasn"t there in 2015, so cant really comment, but was shocked how it turned out.

Pretty sure the same wont happen, just be mindful asking questions that we know they can"t answer. ATB

t

Just asking myself many questions last night, concluding the re are many questions to ask, but i wonder if the BOD would prefer to use the raised funds for SCIB1 trial for Moditope.?

Can"t wait to get some answers next week. Drove myself scatty last night, so many questions for me, and i presume for others.

Just woken up, are those all buys showing on LSE at the moment??

Considering we finished 16% down, i would say they are sells, but you cant tell from trades around that time that they are definately sells. Would the MMs have paid a .30 premium for sells, ???

Cars, missed the 2015 one, thank G-d. disappointed I cant make next week for the same reasons. This is some drop, for a delayed trial??