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Ruck at al, yeah I ended up watching War in the Blood last night too on the link crumbs posted.

Wasn"t going too in the end as I was tired and thought it might be best not to delve into any areas that were emotive atm, but glad I did ""curiousity killed the cat"".

From the first moment it showed the entranve to the McMillan Cancer Centre UCLH, my home for six years, and yes I was aware of this trial back to 2016/7. Will post my thoughts another time, very mixed, but worth the watch, I just wonder how the public who the science was new for perceive Car-T now??

Morning Guys,

Hi Klepto, happy you are still with us LTH, I remember you buying your first tranche just a few months ago. Hope you have been able to add to your holding since, I believe the timing was very good.

Respect your post, but Ray didn"t say he wanted to ramp the company, IMHO he is one of our finest posters with a tremendous understanding of our Science, which far exceeds mine, lol. What he says is.............................

""Something I have been thinking of doing is to pull together all I know about moditope and try to present it in a coherent way."""

I know after seven years I have so much information stored in my mind, I welcomed that post because it is discussing our science, and it always me to draw on my knowledge in a better ""coherent way"". Each to our own, but I also think that every single one of us could benefit in some way. I truly hope we can re cover this, discuss trials and everything Scancell. Good luck to you and to all of us...........................C7

Morning guys. Ray a wonderful idea, that would be so helpful for all of us.

I ended up watching the Documentary on Car-T last night, so still got some sleep in me, will catch you all soon..........c7

Hi Bunsie,

How good to hear from you. A very beautiful post and yes there are many others who I feel indebted to for keeping us informed going back to 2012 and guiding us through the complexities of the Science and beyond. I find it remarkable that so many years on, how few have disappeared. There are many too who have found a preffered platform elsewhere, for whatever reason, and it is to my detrement that for deeply personal reasons I choose not to embrace that platform, as there are many fine posters still posting there.

Had a particularly whirlwind few days so putting on ice my plans to watch that documentary till another time a better time. It was purely the concept of the Science that attracted me here back in the days and I feel very excited that the concepts are soon to become reality. Under no illusions as to timelines now, just have more than a feeling that our patience, our research will soon reward us and more importantly benefit patients who it is a matter of life or death that we are succesful.

Eternally grateful to that wonderful day we spent travelling to the AGM together, it was special for so many reasons , a day I will never forget. Send my sincerest good wishes to Filbert and ""the gals"", and just hope we meet up again, in a different time, it will be a pleasure. Take care, my friend.

Ah, I was under the impression it was on BBC4 tonight, seems like it is not, but the link was posted up earlier, so watching it anyway. lol.

And it ends Volume 74.5k, 2 Buys 72k.............2 Sells 2.5k.............No trades on NEX. Very quiet indeed.

Looking forward to the BBC Car-T Documentary tonight, so much became so very clear after the first one on Melanoma a few weeks back, got no doubt tonights will have a very profound feeling too.

Absolutely delighted the BBC have decided to inform the public in general of so much perhaps only we have been aware of for some time. Makes me feel proud of this BB too overhow much we have discussed on these diseases the last few years, which I feel makes it have that profound effect on us, because we are very aware of melanoma and Car-T by the information we have researched and so many posts on the subjects that we understand it easier as we are more familiar with terminologies that we can get it so much better.

Delighted too that so many newbies can get a deeper understanding of what we have covered over the years, and won"t feel they have missed as much as they think. Somehow for me seeing a 60 minute documentary has a deeper feeling than reading volumes of PDF files, I hope you feel that too.

Becoming ever more comfortable in this share, each passing day since Vupes bought that stake. Yes they have got in IMHO cheap, but that is where i think charity ends. Seems to me we are determined to hold out for a maximum return for shareholders, and yes I do feel funding options in the futurewill be very different to what we have seen the last few years. Since 2013 Vupes have been stalking this share, done their research, due digilence and have pounced at a wonderful opportunity to invest in our Science and take a 17% stake in us. Another huge validation for us, and valuable assets in our boardroom too, quelling some peoples doubts as to the financial astuteness of our BOD. (I hope!!)

As Crumbs was saying, although it has a tragic ending, more and more is being understood from the data gathered, as is always the case in such trials. So try and watch it tonight and catch up with the first in the series on Melanoma recently, it is a must watch. My feeling of being so comfortable is driven by the market converging in our direstion in a way we haven"t seen before.

Goodnight guys, sure there will be some very uncomfortable moments tonight, but that is the reality of the sector we are in, the rewards are ridiculously high, and every month that passes we can see clearer why. Take care

Famous last words eh, lol.

Volume just 73,500...............2 buys and a small sell 1,500

Buys at 7.15, sell at 7.025

Yep, amazing, we are back in the same place again, it is the mechanisms that I am truly starting to understand now, helped largely by the BBC4 Documentary and a couple of items in Ray Pointers post a few days ago, quite apart from the enormous scientific contribution we have been lucky to have read and learned from here.

In the meeting with James Allison, in the melanoma documentary, he said, we are getting close to the time we can mention the C word. That sent tingles through my spine, and lets face it his T Cell work that he was awarded The Nobel Prize for somewhat validates the work of LD and Scancell too.

Two trades, two buys

Glad you mentione that Kite and Juno now have commercial products. For me it seems like the bad news concerning Car-T has diverted from any good news they have had.

I always reckoned it was a worthy part of the Arsenal against cancer, the concept is breathtaking.

Crumbs, did you get to watch the BBC documentary two weeks ago on a mans melanoma, his appt with James Allison and the validations for Immonotherapies? Also a must watch and glad you mentioned the emotional rollercoaster, it is!!!

Been asking myself the same question TF, good link.

Crumbs, yes I have read of many issues, both good/bad, looking forward to watching it later

Thanks Crumbs. Do you remember me posting a while back that my oncologist was leading a Car-T trial at UCLH, which was ended last year in favour of a diagnostic/sequencing trial? Just wondering whether it is the same one.

Morning Guys, was this not the BBC 4 Documentary on Car-T , I thought scheduled for tonight??

Wild, thanks buddy. Maybe people should know we have spoken once, met twice and messaged maybe on 3 occasions. And yes I consider you a friend too. That is why I fight to clear the slurs given to us, very few know you at all, at least we have met twice, and that a pleasure as are your posts.

There is no ramping here, as accused, just more than a few of us who believe in the work we are doing to different degrees. Are we all wrong? And I don"t mean will the share price go up or down in the coming week? I was actually surprised at the reaction to the last RNS, I wasnt sure whether the market would like it but they did, and the following day liked it more. I privately thought we would end the week 7/7.50, but we didn"t it was 7/7.30, and i was happy with that. A lot of profit for those who bought sub4p/5p, and we are trading up IMHO. I didn"t trade myself my ave of 14.8p looks so much better than at 3.60 and my belief we are going higher makes this a no trade for me.

Not expecting passionate news this week, but we could, expecting something pre I nvestors Show, but aware of the AIM market who knows where we go next.? Hopefully to the moon given time. Yeah been a heck of a day, no different to what so many have experienced For me the positive posters give reason to their thoughts, the negative ones give just an opinion and not IMHO.

So good luck to us all, may the share provide what we need, and that for me is great trial data amongst a few other items. Negative views are always welcome, but lets give reason for them so we can debate it, and hopefully that starts tomorrow. Sleep well guys, till tomorrow.

And thank you for your very heartfelt post. If I never hear the words ramper/deramper again it couldn"t come sooner.

Unfortunately we only have a few lines to make a point, misunderstanding and clarity often goes out of the window.

As you say we all agree on more than we disagree, lets all bring some dignity back to this BB...............ATB Ruck and pleased about your father.......................C7

Knowlesi, I really do hope this draws the line between the two of us. I never said your ""personal attacks against me"", I clearly stated.............................................

""I will leave it to you to consider drawing a line in your very personal attacks against so many"". So you are still twisting, and I shall put on the filter again.

Sadly I have just heard my brother has passed away this morning, I have been estranged from my beautiful niece and nephew during the last couple of years too, I have just spoken to them both and they badly want me back in their lives. I need them too. That is what my brother would want too. So, you decide what you do, but stop this twisting of words, I never mentioned you and me, just offered my gratitude for your thoughts.

Take care all, life is very precious............................

Morning All.

Knowlesi, appreciate your message so very much, as I do to so many others and really hope now we can draw a line under it. The reality is as mad as it sounds, the source of my disabilities and reason why I am mostly housebound have not changed, and as Widforce notice it is hugely tempered by my brother who is in North London Hospice, the same one that helped me for so long with pallative care in his final days after a series of treatments like mine failed to clear his tumours and sarcomas in his lung. So just waiting for my phone to ring, and my heartbreak in us being estranged for the last few years is bearing down heavily on me. I saw him last week and I guess I am in shock.

It is my sincere hope that anybodywho has read my posts will have picked up my gratitude for the excellence of UCLH, the bond between patients and cancer workers, and despite ridiculous odds it is possible to survive and is testement to what we are starting to hear more of. Unfortunately the same hospial, same consultants and surgeon unbeknown to me have failed to save my brother, which just shows us the cruel randomness of the disease. I hope too people have noticed that I had just about given up a couple of years back, and we consider the mental toll it takes on patients and triallists. My treatments a few are far from over.

I hope sincerely that nobody feels I have tried to ramp this share on the back of my illness, but when I say I have never felt more comfortable in this share, that comes from a place where over six years in treatment I have learnt about so much in this disease and from a share I had casually invested in, I have learned, especially after watching that documentary on BBC4 recently we are so in the right place, at the right time. I pray our trials go well, I have seen hundreds of patients, and it is from their courage and in some case brutal treatment regimes that gave me any courage i found to fight this, even down to getting to the hospital in recent times. I am no expert in cancer, but will humbly suggest I now a hell of a lot more than some just from my experiences, and as far as trading a share am just a bit better than useless.

I really hope Knowlesi we can put an end to the unpleasentness that has surrounded this share for so many years, as I have said to you so many times we DON"T disagree on Scancell issues at all, in fact your bullishness long term exceeds mine, it is just the journey we take that we differ there for sure I am more bullish than you.

I will leave it to you to consider drawing a line in your very personal attacks against so many, you are far better than that, as you have demonstrated now. Again many thanks, your sincerity I have never doubted. Take care and yes hope to see you at the AGM. ATVB

Just wanted to clarify my hope that we receive news about patient recruitment for the SCIB 1 Combo Trial by the time of the Investor Show on the 17th of this month From the last RNS H1 Update dated 1st July...........................

SCIB1 Phase 2 trial

""""As reported in April, the Company has received the necessary regulatory and ethical approvals to initiate the UK arm of the SCIB1 clinical trial. Operational activities for clinical centre initiation have been completed and active patient recruitment is anticipated in the coming weeks!!!!

So as unfortunately timelines often leave questions from RNSs, I am presuming IMHO that the""" coming weeks"" will mean from the 1-17th July which I think is a reasonable expectation/hope, which will be Wednesday a week.

Goodnight.

Would agree with that rats, as so many other treatments and combo trials have returned good data but with limited success in certain indications, those are the benchmarks we set about chasing now. Whilst checkpoint inhibitors gave cause to see so much progress their limitations too have been well documented and exposed. The billions spent by Big Pharma on those alone and they need us to perform at their peaks.

Yeah a very exciting time, and hoping we get news of succesful patient recruitment just before the Investors Show on the 17th July and whatever other news becomes available by then.

ATB