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Yep having a Universal Covid Vax so eliminating the need to worry about variants is a the best solution.
However the current mRNA can be modified much more quickly and easily almost as a kind of plug and play to cope with new variants than traditional fku models which are based on predicting prevalent antigenic strains.
Even without a universal Vaccine think most Scientists are quite comfortable with current Covid Vaccine Technology backed up by Aggressive Test and Trace in terms of overcoming current and future variants but if SCLP can fulfil its promise it will be a big step forward
Yes, Ivy, I suppose its like updating the flu vaccine, but as Inan says you have a vaccination bottleneck, maybe year after year.
Hi Ray.
I presume they mean more than one antigenic strain to deal with different variants so they just add a new strain to the existing mRNA Vaccine to protect vs the variants for eg SA or Brazilian strain.
See the Govt has also suggested rather than put these new Vax through a p3 they will just Approve based on measuring lab based results
Then when Covidity is shown to work on the N protein, the world will want 7 billion doses, job done! Thank you Lindy :-)
https://www.youtube.com/watch?v=tbU3zdAgiX8
I suppose in this context "multi valent" may mean it is aimed at different known variants of the S protein i.e. playing catch-up.
"In February 2021 CureVac and the British pharmaceutical company GlaxoSmithKline (GSK) agreed to jointly develop next-generation ***multi-valent mRNA vaccines against COVID-19***. The development of new vaccine candidates is strengthened by a partnership with the UK Government and its Vaccines Taskforce, which CureVac also entered in February 2021."
Ray, this can be found at the bottom of CVAC press releases. The only clue is multi-valent.
"If this is the case then IMO it could be still lagging behind what Covidity may provide. It could be 1st gen+ but not really 2nd gen."
I'm sure Inanaco said exactly this on A D V f N, i.e. it's not a true next gen?
Hi hyms
Thanks for pointing that out.
I wasn't quite sure whether the document I posted related to the vaccine that the UK government has ordered.
Do we know whether the new curevac vaccine is an update on their first vaccine i.e. it is taking into account known spike protein variants?
If this is the case then IMO it could be still lagging behind what Covidity may provide. It could be 1st gen+ but not really 2nd gen.
Your comments would be most welcome.
Thanks for sharing that Ray. That chunky doc looks like CureVac current trial?
It is an mRNA vaccine but the vaccine design doesn't incorporate N-protein antigen. This P3 trial isn't complete yet.
The UK gov order is for the CureVac next generation variant vaccine --- for which they'll need to start a new trial. My feeling overall is our CT's are more complex to design but not outside our scientific capabilities.
The fact that the government has secured an order just shows UK government handling of this crisis (probably close to 500M vaccine doses ordered in total just by UK). You need to wait for Scancell + consortium to make some announcements first about this, trials etc. It's a little known company, not a 4B mcap.
Where Lindy's approach may prove to be superior is that she identifies specific epitopes (i.e portions of a protein) as the best to target and then Immmunobody in combination with Avidimab activates the T Cells that match those epitopes.
Because of Immunobody's dual presentation aspect the activated T Cells have high avidity (ability to stay attached to the target) and also strong clonal expansion (the T Cells splitting to produce identical copies).
It is this high avidity and strong clonal expansion that may turn out to be key to Covidity's success.
As far as I know mNRA vaccines are messages to instruct the body on how to produce a protein, so yes this applies to any protein including the N protein.
https://www.curevac.com/wp-content/uploads/2020/12/20201214-CureVac-HERALD-Clinical-Trial-Protocol-of-Phase-2b_3_CVnCoV.pdf
This description of a clinical trial mentions the N protein in connection with antibodies but there doesn't seem to be a mention of testing a T Cell response to the N protein.
"Well mRNA and logistical issues aside - they have secured an order!"
A very fair point! However as IB888 says, this is old news is it not?
Also can mRNA vaccines target the n protein, and if so does this Curevac one do it?
Well mRNA and logistical issues aside - they have secured an order!
The Curevac deal is not new post budget news. It was announced by the Government on the 5th February.
The Curevac one is mRNA again isn't it? Same logistical issues as with the others?
Well I hope CH is pitching to the government procurement team right now.
Looking forward to hear how many doses he has secured.
Reported by BBC today. Presumably no threat to our more sophisticated vaccine?
"Experts are already working on updating coronavirus vaccines. The UK government has announced a deal with biopharmaceutical company CureVac to develop vaccines against future variants, with a pre-order of 50 million doses."