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Thanks Hoolicat, proper scientific explanation. I think the BBC will gradually get there. We do need a few more scientists working in journalism imho. I have an arts/management background and I feel like I have a better handle than most of them. They just don't even keep up to date so they have no confidence to properly interrogate or interpret the debate.
Hoolicat, would you consider calling into one of the weekend shows - Question Time or something?
The bbc are scum buckets . Nowadays they even do not know what they stand for anymore. inmho
https://www.bbc.co.uk/news/education-54697113
Lateral flow home tests to be used in uni before xmas
This BBC news is full of holes and very disappointing as it is setting off all sorts of hares. The immune system has two basic levels, innate and adaptive. The innate system consists of antibodies that are always being produced and circulating, patrolling if you like, with a variety of common antigen sites, so that it is the first of the mark if antigen from a foreign body invaded and it ramps up immune response. If the antigen is novel or rare, then this system will take time and you will get a more serious infection. The important point for innate antibodies is that they are always present at high levels in a healthy immune system, produced by a subset of B white cells.
The adaptive system is where having been infected by an antigen, a different subset of B Cells produce a specific antibody targeted for that specific antigen...now the immune response is in full swing. These antibodies will stay at high levels as long as exposure is continued, but if not needed will fall again as it is inefficient to keep pumping out specific antibodies...over a lifetime we would just be a big bag of antibody otherwise! However the B cells retain a memory so that the response will be faster if attacked again.
A poor analogy would be innate antibodies are your “homeguard”, always on patrol but not brilliant at a big invasion. But once they set up the alarm and first response, the adaptive antibodies, the “special forces”, are produced and hopefully destroy the invader.
So, why is the bbc report poor? Because 1) the study has not tested the same group of people to see if their antibodies are declining and how fast. They have tested a new group, so there are many factors that can alter the level, the first batch may just have had more people with antibodies. Even if it is the case that antibodies decline rapidly after infection, it still does not mean you will get infected again due to the B cell memory, or it may be more mild whilst production is ramped up again.
So basically we have to have a lot more evidence from studies to work out how long antibodies hang around and then when they do decline how long it takes to mount a second immune response. So again the news is producing a whole load of unnecessary speculation and panic! But this may still help us of course!
And the Long Term Holders know what is coming. All the best in your future endeavours.
19th October RNS. It tell you that its 100,000
The majority of the new ODX holders are clueless. They've just followed the herd. I will leave you all in peace. GLA
No you hang up. No, no you hang up.
MB
I have emailed and been told. You can contact WB too.
At the moment, capacity is only 100,000 week
End of November it will be 200,000 per week
In the new year, they will make 500,000 per week
CK mentioned 2.5m per week next year too but for that, a gov funding may be needed. If not use the profits if any or dilute.
Currently, its 100k. How much of it going to Mologic antibody, how much of it for UKRTC, no idea. No clarity.
I left because things are clear as mud when it comes to capacity and it for me is paramount.
We all know how good the ukrtc test is as well as the mologic antibody, if you don;t have capacity for it, you cant make profits. I think you should ask if you are not sure.
We are manufacturing at the capacity that we were told we would be manufacturing at, it's all clearly stated in the RNS and Presentations. Don't understand why your still confused. Anyway good luck on your new ventures and make sure to close the door on your way out.
iPhone - how do you know how many tests a week we are currently making? I'm sure tomorrow will help clear things up, which is the point of a trading update. It sounds like we have capacity for 200k mologic and 200k UK RTC, plus we have Visitect CD4 tests on run. Equipment takes time to procure, there is more than one piece of kit required, it's all in the last presentation. They need a second site to get to 1m. It's clear they are looking at a bigger plan than what was in the fundraise prospectus. Not really much to worry about.
For God's sake do some research. The whole point of vaccines is to increase the Antibody response because the present patient response is zero or not effective enough. Antibody tests will enable vaccines to be screened on an individual basis to check for a response to the vaccine.
Any chance you could shut the door behind you and leave us in peace or is the clue in the name.
MB
I have a lot of time for you and you've been great on this BB. I've been here ages. I even bought 40p placing only to see us drop to on the same day.
We saw a new machine all setup and the twitter message told us 500k per week.
So why are we still doing 200k?
Which test is running at what capacity? I cant get an answer.
Capacity is paramount for ODX as they're just a manufacturer and if we're ding 200k a week, with now only 3 tests instead of 5, i don't think we'll meet the target earnings.
If 500k is from next year, why twit a pic of the machine all setup 2 months ago.
Too many questions has left me to pull out. GLA
Sounds like they are discussing REACT2 which used the fortress diagnostics test.
Ive not seen the data (not sure if its even published) but we know that fortress did not meet MHRA target of 98% sensitivity. A lot of the time a test will fail sensitivity specs as it fails to pick up low concentration samples (The limit of detection of the assay is not low enough)
It could well be the case that after a certain period of time antibody presence is below the detection limit of fortress and so they test negative for antibodies. in theory a more sensitive test likely has a better LoD and therefore will detect antibodies for a longer period of time even if they are declining
Hasnt this subject been raised like 100x I thought it was tested and excepted - 5 to 7 months. Even if you have antibodies im guessing you can always be infected again - just the antibodies fight it off
But just to repeat again - isnt that what antibody test will do - say when you are depleted. when a vaccine has worked or when its stopped - when you need a top up. they will confirm to air carriers you are safe - same for festivals and sports places.
And of course antigen tests will be needed for the same reason - both in the hundreds of millions
If it doesn't last long, i doubt the gov will want to roll out free tests to every house hold like originally planned. ODX needs MHRA to sell for home use and that is going to take ages it seems. I was told the approval process is like WHO, FDA meaning it can take months. I have pulled out as i can't get a cear answer on capacity. 100k, 200k, 500k, 1m, 2.5m What the hell is it?
The twitter pic told us 500k a week.
We then get FINCAAP running estimations at 200k which makes the earning for this year cr@p.
The gov contract is for professional use only. The money for me is in home use. GLA
Declining antibodies means coronavirus is going to be around much longer, it means that people with a positive test will need repeat testing and it means more testing to monitor the efficacy of any vaccine. So if this is the case the testing opportunity is so much bigger than if it is not.
It doesn't matter if Antibodies don't last long, the truth is ODX has a contract with the UK govt and Antibody tests are being sold to them as we speak. Orders will be increased next week which means the SP will rise. £1 will soon be our baseline so y'all better jump on board before it starts rising again.
Antibodies don't last long. BBC1.
Study by imperial college
Coming up....
watch it.
Does it impact ODX