Transaction in Own Shares

International Biotechnology Trust plc (the "Company")

Transaction in own shares

The Company announces that on 28 June 2016 it made a market purchase of 30,000 of its own Ordinary shares of 25p each, representing 0.08% of the issued share capital (excluding treasury shares). The shares were bought at 435.0p per share and the Company intends to hold these shares in treasury. These shares will only be re-issued at discounts which are less than the discounts at which the shares were bought.

Following this purchase, there are 37,912,663 Ordinary shares in issue (excluding treasury shares) and 4,130,000 Ordinary shares held in treasury.

Nariman Ghandhi

For and on behalf of

BNP Paribas Secretarial Services Limited

Company Secretary

Telephone: 020 7410 5971

28 June 2016