Total Voting Rights

6 February 2020

Open Orphan plc

("Open Orphan", the "Company" or the "Group")

Total voting rights

In conformity with the FCA's Disclosure Guidance and Transparency Rules, following Admission of the Placing and Subscription Shares, the Company confirms that as at the time of this announcement, its issued share capital consists of 532,507,581 ordinary shares of 0.1 pence each ("Ordinary Shares"). All of the Ordinary Shares have equal voting rights and there are no Ordinary Shares held in treasury. This figure of 532,507,581 Ordinary Shares represents the total voting rights in the Company and may be used by shareholders as the denominator for the calculations by which they can determine if they are required to notify their interest in, or a change to their interest in, the Company under the Rules.

Capitalised terms in this announcement shall have the same meanings given to such terms in the Group's announcement at 7.00 a.m. on 31 January 2020.

For further enquiries, please contact:

Open Orphan plc

Cathal Friel, Executive Chairman +353 (0)1 644 0007

Trevor Phillips, Chief Executive Officer +44 (0)20 7347 5350

Arden Partners plc (Nominated Adviser and Joint Broker) +44 (0)20 7614 5900

John Llewellyn-Lloyd / Benjamin Cryer

Davy (Euronext Growth Adviser and Joint Broker) +353 (0)1 679 6363

Anthony Farrell

Camarco (Financial PR) +44 (0)20 3757 4980

Tom Huddart / Daniel Sherwen