Publication of Final Terms

SANTANDER UK PLC€35 BILLION GLOBAL COVERED BOND PROGRAMMEPublication of Final Terms - Series 22 Tranche 5

The following final terms (the Final Terms) are available for viewing:

Issue of Series 22 Tranche 5 €132,500,000 Fixed Rate Covered Bonds due 24 January 2018 (ISIN XS1486588970) under the €35 billion Global Covered Bond Programme of Santander UK plc (the Programme) (to be consolidated, become fungible and form a single Series with the existing Series 22 Tranche 4 €117,500,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 24 May 2012, Series 22 Tranche 3 €300,000,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 27 March 2012, Series 22 Tranche 2 €350,000,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 20 April 2011 and Series 22 Tranche 1 €750,000,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 24 January 2011 (ISIN XS0582479522)).

To view the full Final Terms document, please click on or paste the following URL into the address bar of your browser:

http://www.rns-pdf.londonstockexchange.com/rns/3760J_-2016-9-8.pdf

A copy of the above Final Terms has been submitted to the National Storage Mechanism and will shortly be available for inspection at www.Hemscott.com/nsm.do.

The Final Terms can also be viewed via:

http://www.santander.co.uk/uk/about-santander-uk/debt-investors/santander-uk-covered-bonds 

Please see Annex 1 to this notice for additional information in relation to the Series 22 Tranche 5 Covered Bonds.

For further information, please contact:

Medium Term FundingSantander UK plc2 Triton SquareRegent's PlaceLondon NW1 3AN

Tel: +44 (0) 20 7756 7100

Email: mtf@santander.co.uk

DISCLAIMER - INTENDED ADDRESSEES

Please note that the information contained in the Final Terms and the base prospectus published in respect of the Programme on 1 June 2016, as supplemented on 30 June 2016, 27 July 2016 and 16 August 2016, (the Prospectus) may be addressed to and/or targeted at persons who are residents of particular countries only (as further specified in the Prospectus) and is not intended for use and should not be relied upon by any person outside these countries and/or to whom the offer contained in the Final Terms and the Prospectus is not addressed. Prior to relying on the information contained in the Final Terms and the Prospectus you must ascertain from the Final Terms and the Prospectus whether or not you are part of the intended addressees of the information contained therein. Your right to access this service is conditional upon complying with the above requirement.

ANNEX 1

ADDITIONAL INFORMATION IN RELATION TO SERIES 22 TRANCHE 5 €132,500,000 FIXED RATE COVERED BONDS DUE 24 JANUARY 2018

OPERATIONAL INFORMATION DOCUMENT

This Operational Information Document related to the Final Terms dated 5 September 2016 (the Final Terms) in respect of the issue of Series 22 Tranche 5 €132,500,000 Fixed Rate Covered Bonds due 24 January 2018 (ISIN XS1486588970) (to be consolidated, become fungible and form a single Series with the existing Series 22 Tranche 4 €117,500,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 24 May 2012, Series 22 Tranche 3 €300,000,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 27 March 2012, Series 22 Tranche 2 €350,000,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 20 April 2011 and Series 22 Tranche 1 €750,000,000 4.375 per cent. Covered Bonds due 24 January 2018 issued 24 January 2011 (ISIN XS0582479522).

This Operational Information Document has not been reviewed or approved by any competent authority for the purposes of the Prospectus Directive or otherwise and does not form part of the Final Terms for the purposes of the Prospectus Directive. However, for all other purposes this Operational Information Document must be read in conjunction with the Final Terms. Words and expressions which have a defined meaning in the Final Terms or Base Prospectus have the same meanings in this Operational Information Document.

 DISTRIBUTION

(a) If syndicated, names of Lead Managers: Not applicable

(b) If not syndicated, name of relevant Dealer: Santander UK plc

(c) U.S. Selling Restrictions: Regulation S