Presents Data on Lead Programme SLN124 at EHA

Silence Therapeutics Presents Data on Lead Programme SLN124 at 23rd Annual European Hematology Association Congress

15 June 2018

Silence Therapeutics plc, AIM:SLN ("Silence" or "the Company") a leader in the discovery, delivery and development of novel RNA therapeutics for the treatment of serious diseases with unmet medical need, announces today it will be presenting data on its siRNA conjugate technology and lead candidate SLN124, for the treatment of iron overload disorders at the 23rd Annual European Hematology Association (EHA) Congress held on 14-17 June, 2018 at Stockholmsmässan: Mässvägen 1, 125 80 Älvsjö, Sweden.

Dr Ute Schaeper, Drug Discovery Project Leader, will give an oral presentation (S893) entitled "Development of a GalNAc-siRNA Conjugate Targeting TMPRSS6 for the Treatment of Iron Overload Disorders, such as Beta-Thalassemia" on Saturday, 16 June at 16:30 CEST. The presentation will be part of the 'Iron: From basic science to clinical application' session held in Room A13.

The data to be presented demonstrate that GalNAc-siRNA conjugate SLN124 is a promising candidate for the treatment of iron overload and anaemia in Beta-Thalassemia and related disorders. SLN124 is undergoing preclinical development and is planned to enter the clinic in 2019.

Dr Ute Schaeper, Drug Discovery Project Leader at Silence Therapeutics, commented: "Our studies demonstrate that GalNAc-conjugated siRNA designed to silence TMPRSS6 in hepatocytes may provide a safe, effective and patient-friendly therapeutic option for the treatment of iron overload disorders. SLN124 shows dose-dependent and long-lasting effects on target levels as well as on modulation of iron stores and normalisation of erythropoiesis in relevant disease models. We believe that SLN124's mechanism of action and profile will potentially deliver an improved approach to patients in need."

The presentation will be available on the Company's website: www.silence-therapeutics.com

To view the full abstract; please visit https://ehaweb.org/congress/23rd-c/program/online-program/

Notes to Editors

About Silence Therapeutics plc

Silence Therapeutics is developing a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, within its cells. Our proprietary technology can selectively inhibit any gene in the genome, specifically silencing the production of disease-causing proteins. Using our enabling delivery systems, we have achieved an additional level of specificity by delivering our therapeutic RNA molecules exclusively to target cells. Silence's proprietary RNA chemistries and delivery systems are designed to improve the stability of our molecules and enhance effective delivery to target cells, providing a powerful modular technology well suited to tackle life-threatening diseases. For more information, please visit: http://www.silence-therapeutics.com/