Notice of General Meeting

22 August 2016

Physiomics plc

("Physiomics") or ("the Company")

Shareholder Circular and Notice of General Meeting

Physiomics plc (AIM: PYC), the Oxford, UK based systems biology company, is pleased to announce that it has today published and posted to shareholders a circular in relation to a forthcoming General Meeting, due to be held at the Company's registered office, The Magdalen Centre, Oxford Science Park, Robert Robinson Avenue, Oxford, OX4 4GA at 10:00 a.m. on 7th September 2016.

The directors will propose at the General Meeting shareholder resolutions seeking consent to allot shares and for the dis-application of pre-emptive rights.

A copy of the Circular is available on the Company's website (www.physiomics-plc.com/investors/reports-prospectus/).

Enquiries:

Physiomics plc

Dr Jim Millen, CEO

+44 (0)1865 784 980

WH Ireland Limited (nomad/joint broker)

Katy Mitchell

+44 (0) 161 832 2174

Hybridan LLP (joint broker)

Claire Louise Noyce

+44 (0) 203 764 2341

About Physiomics plc

Physiomics (AIM:PYC) is a computational systems biology services company applying simulations of cell behaviour to drug development to reduce the high attrition rates of clinical trials. 80-90 per cent of all clinical drug candidates fail to reach the market and estimates show that an overall ten per cent improvement in success rates could reduce the cost of one drug's development by as much as $242 million, from the current estimate of around $800 million1.

Physiomics develops computational systems biology models to predict and understand cancer drug efficacy from pre-clinical research to clinical development. Physiomics has created detailed mathematical models incorporating the most important molecular events taking place during the human cell cycle and apoptosis processes. The company's SystemCell® technology enables the simulation of populations of "virtual cells". The company has also developed a "Virtual Tumour" model to simulate the effect of anti-cancer drugs on tumour growth. The models are used to optimise compound design and to design drug schedules and combination therapies.

Physiomics, based in Oxford, UK, was founded in 2001, and floated on AIM in 2004. For further information, please visit www.physiomics-plc.com

SystemCell® is a registered trademark of Physiomics plc

1Tufts Centre Impact Report 2002