Issue of Shares to Director

4 December 2013

Biome Technologies plc

("Biome", "the Company" or "the Group")

Issue of shares to a Director

Further to the Company's announcement of 28 March 2013, the Company has today issued 7,742 new ordinary shares of 5p each ("Ordinary Shares") to Leapacross Ltd ("Leapacross"), a company of which John Standen is a director and the majority shareholder, in consideration for the third tranche of the consultancy agreement with Leapacross. Following this issue, Mr Standen is now interested in a total of 48,836 Ordinary Shares, equal to 2.08% of the issued share capital of the Company. Of these shares, Mr Standen holds 10,000 Ordinary Shares in his own name, 10,000 Ordinary Shares are held by his wife, Mrs K M Standen, and 28,836 Ordinary Shares are held by Leapacross.

Application has been made for these 7,742 Ordinary Shares to be admitted to trading on AIM. Dealings are expected to commence on 10 December 2013.

Following this issue of equity, the total number of Ordinary Shares in issue is 2,347,536 (the total number of voting rights in the Company). This figure may be used by Shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, Biome under the FCA's Disclosure and Transparency Rules.

-Ends-

For further information please contact:

Biome Technologies plc

Paul Mines, Chief Executive Officer

www.biometechnologiesplc.com Tel: +44 (0) 2380 867 100

Daniel Stewart & Company plc

David Hart/James Thomas

www.danielstewart.co.uk Tel: +44 (0) 20 7776 6550

First Columbus

Chris Crawford/Kelly Gardiner

www.first-columbus.com Tel: +44 (0) 20 3002 2070

FTI Consulting

Oliver Winters/Latika Shah Tel: +44 (0) 20 7831 3113