Issue of Equity

Polar Capital Holdings Plc (the "Company")

18 October 2016

Issue of Equity

Application has been made to AIM for the admission of 29,226 new ordinary shares of 2.5 pence each in the Company to trading (the "New Shares"). The New Shares, which will rank pari passu in all respects with the Company's existing shares in issue, have been allotted pursuant to the exercise of options by employees of the Company. Admission of the New Shares is expected to become effective on 24 October 2016.

Following the issue of the New Shares the total number of ordinary shares of 2.5p each (the "Ordinary Shares") in the Company with voting rights will be 91,363,017. The Company does not hold any Ordinary Shares in Treasury.

The above figure of 91,363,017 Ordinary Shares may be used by shareholders in the Company as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the share capital of the Company under the Financial Conduct Authority's Disclosure and Transparency Rules.

For further information please contact:

Polar Capital

Neil Taylor (Company Secretary)

+44 (0)20 7227 2700

Canaccord Genuity

Simon Bridges

Andrew Buchanan

Kit Stephenson

+44 (0)20 7523 8350