Investor Day

23 October 2013

INVESTOR EVENT

On Monday 18th November 2013, Silence Therapeutics is hosting an Investor event for investors and analysts in London. The purpose of the event is to explain the background to Silence's technology and outline its potential. No material new information will be presented.

For further information please contact:

Silence Therapeutics plc

Timothy Freeborn, finance director

Annie Cheng, director of corporate development

 +44 (0)333 988 0140

t.freeborn@silence-therapeutics.com

a.cheng@silence-therapeutics.com

N+1 Singer

Shaun Dobson/Jenny Wyllie

+44 20 7496 3000

shaun.dobson@n1singer.com

jenny.wyllie@n1singer.com