Holding(s) in Company

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

Proteome Sciences plc

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

Yes

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached 

No

An event changing the breakdown of voting rights

No

Other (please specify):______________

No

3. Full name of person(s) subject to notification obligation:

Sanofi-Aventis Deutschland GmbH

4. Full name of shareholder(s) (if different from 3):

5. Date of transaction (and date on which the threshold is crossed or reached if different):

23th October 2009

6. Date on which issuer notified:

13th November 2009

7. Threshold(s) that is/are crossed or reached:

7%

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

GB0003104196

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares

9,455,024

Number of voting rights

9,455,024

Number of shares

 8,354,579

Number of voting rights

Percentage of voting rights

Direct

 8,354,579

Indirect

Direct

6.29%

Indirect

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period/date 

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

N/A

N/A

N/A

N/A

N/A

Total (A+B+C)

Number of voting rights

Percentage of voting rights

 8,354,579

6.29%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

Juergen Blieke or Reiner May

15. Contact telephone name

0049 69 305 4703 or 0049 69 305 80202

16. Contact address