Director/PDMR Shareholding

e-Therapeutics plc("e-Therapeutics" or the "Company")

Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons

The Company was informed today that Steve Self, an Executive Director, purchased on the 10 March 2011 26,677 ordinary shares at 37.5p per share. His resultant total holding is 113,090 shares representing 0.08% of the issued share capital of the company which currently stands at 137,193,547 shares all carrying voting rights.

14 March 2011.

For more information, please contact:

e-Therapeutics plc

Malcolm Young / John Cordiner

Tel: +44 (0) 191 233 1317

E-mail: malcolm@etherapeutics.co.uk

www.etherapeutics.co.uk

Panmure Gordon (UK) Limited

Andrew Burnett / Aubrey Powell

Tel: +44 (0) 20 7459 3600

www.panmuregordon.com