Directorate Change (Conference call)

Banco Santander, S.A. ("Banco Santander"), in compliance with the Securities Market legislation, hereby announces:

OTHER RELEVANT INFORMATION

Pursuant to the inside information announcement disclosed today to the Spanish National Securities Market Commission (CNMV), related to Héctor Grisi who has been nominated to succeed José Antonio Álvarez as CEO of the Group, Banco Santander hereby communicates that a conference call with Ana Botín, José Antonio Álvarez and Héctor Grisi will take place today Friday 17 June 2022, at 14.00 CET.

To follow the presentation, please register using the following link:

https://cossprereg.btci.com/prereg/key.process?key=P3AP4WC4N

Once registered, the telephone number for the conference call and passcode will be provided.

Boadilla del Monte (Madrid), 17 june 2022