Compliance with Market Abuse Regulation

INTERNATIONAL BIOTECHNOLOGY TRUST PLC (the Company)

Compliance with the Market Abuse Regulation (MAR) - Share buy backs

The Company announces that it is satisfied that all inside information which the Directors and the Company may have in the period leading up to the announcement of the half yearly results for the half year ended 28 February 2017 has been notified to a Regulated Information Service (RIS). The Company is therefore not prohibited from purchasing its own securities during the closed period (as defined by MAR) which ends on the date of the announcement of the Half Yearly Financial Report.

If, in the period leading up to the announcement of the Half Yearly Financial Report, the Directors or the Company come into possession of any inside information, this will be notified to a RIS before any such transactions are undertaken.

The closed period to which this notification relates is in respect of the half year ended 28 February 2017.

Susan Gledhill

For and on behalf of

BNP Paribas Secretarial Services Limited

Company Secretary

Tel: 020 7410 5971

22 MARCH 2017