Cancellation of Treasury Shares

International Biotechnology Trust plc (the "Company")

Cancellation of Treasury Shares

In accordance with Listing Rule 12.6.4R, the Company advises that on 14 July 2016 it cancelled from treasury 275,000 Ordinary shares.

Following the above cancellation, the Company holds a total of 3,895,000 of its Ordinary shares in treasury and has 37,872,663 Ordinary shares in issue (excluding treasury shares).

Susan Gledhill

For and on behalf of

BNP Paribas Secretarial Services Limited

Company Secretary

Telephone: 020 7410 5971

14 July 2016