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Motif Bio plc

("Motif Bio" or the "Company")

28 July 2016

MOTIF BIO FILES PRELIMINARY PROSPECTUS FOR PROPOSED U.S. PUBLIC OFFERING OF AMERICAN DEPOSITARY SHARES AND APPLIES FOR NASDAQ LISTING

Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announces that, further to the notification on 13 July 2016 of the filing of a registration statement with the United States Securities and Exchange Commission (the "SEC") relating to a proposed public offering of American Depositary Shares ("ADSs") and listing of ADSs on the NASDAQ Global Select Market, the Company has filed an amended registration statement with the SEC, which includes a preliminary prospectus for the proposed offering.

SunTrust Robinson Humphrey, Inc. and Ladenburg Thalmann & Co. Inc. are acting as the book-running managers for the offering.

A registration statement relating to these securities has been filed with the SEC, but has not yet become effective. These securities may not be sold, nor may offers to buy these securities be accepted, prior to the time the registration statement becomes effective. This press release shall not constitute an offer to sell or a solicitation of an offer to buy any securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

The offering will be made only by means of a prospectus. Copies of the preliminary prospectus relating to the offering may be obtained from SunTrust Robinson Humphrey, 3333 Peachtree Road NE, 9th Floor, Atlanta, GA 30326, Attention: Prospectus Department; Email: strh.prospectus@suntrust.com; Telephone: 404-926-5744; or fax: 404-926-5464.

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About Motif Bio

Motif Bio is a clinical-stage biopharmaceutical company, engaged in the research and development of novel antibiotics designed to be effective against serious and life-threatening infections in hospitalized patients caused by multi-drug resistant bacteria. Our lead product candidate, iclaprim, is being developed for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and hospital acquired bacterial pneumonia (HABP), including ventilator associated bacterial pneumonia (VABP), which is often caused by MRSA (methicillin resistant Staphylococcus aureus). We are currently enrolling and dosing patients in two global Phase 3 clinical trials with an intravenous formulation of iclaprim, for the treatment of ABSSSI, which are expected to complete in the second half of 2017.