INS.L Regulatory News (INS)

Instem plc

("Instem", the "Company" or the "Group")

Publication of circular and notice of General Meeting

Instem announces that a circular containing further information on its recent fundraise (the "Circular") was posted to Shareholders on Tuesday 30 June 2020. The Circular also contains notice of General Meeting (the "General Meeting") and accompanying Form of Proxy.

The General Meeting will be held at 2 Diamond Way, Stone Business Park, Stone, Staffordshire, ST15 0SD at 11 a.m. on 16 July 2020.

In light of the COVID-19 pandemic, Shareholders and their proxies will not be allowed to attend the meeting in person, as to do so would be inconsistent with current government guidelines as published as at the date of this document, in particular in relation to the advice for people to avoid public gatherings.

The business of the General Meeting will be restricted to the purposes set out in the formal notice of General Meeting. There will be no additional presentations or opportunities for the Board of Directors to answer questions. The Company's advisers and other guests are also being asked not to attend.

Should you wish to raise any questions ahead of the General Meeting please do so via email to the Company Secretary at investors@instem.com.

These steps are being taken to promote the health and wellbeing of the Company's Shareholders and employees, but it remains important to the Directors that votes are counted at the General Meeting. All Shareholders are therefore strongly encouraged to submit their votes on the formal business to be transacted using the Form of Proxy.

The Company will continue to monitor developments relating to COVID-19. If a situation should arise which necessitates that the arrangements for the General Meeting be altered, Shareholders will be notified promptly via an RNS announcement and the Company's website at https://investors.instem.com.

The Circular, notice of General Meeting and accompanying Form of Proxy, are also available on the Company's website, www.instem.com, in accordance with AIM Rule 20.

Capitalised terms used in this announcement shall, unless defined in this announcement or unless the context provides otherwise, bear the same meaning ascribed to such terms in the Circular.

For further information please contact:

Name of authorised official of issuer responsible for making notification:

Nigel Goldsmith

Company Secretary to Instem plc